Poster 306 Clinical Characteristics of Cervical Dystonia: Differences between Patients Previously Treated with Botulinum Neurotoxin Type A and Naïve Patients
Bibliographic record
Abstract
P. Maisonobe: Employment - Ipsen To compare the clinical characteristics (as assessed by Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)) of naïve patients with cervical dystonia (CD) presenting for treatment to those previously treated with BoNT-A who are at the end of their injection cycle and requiring reinjection. A meta-analysis was conducted on the baseline data from 3 observational studies. A pre-planned interim analysis were used for one of the study (INTEREST IN CD2). 2 international studies (INTEREST IN CD1 & 2, with 9 and 8 countries, respectively) and 1 US registry (ANCHOR-CD). 752 patients with idiopathic CD (616 previously treated with BoNT-A and 136 naïve). Not applicable TWSTRS There were no significant differences between subgroups in terms of patient demographics, but small differences in the predominant pattern of CD (previously treated vs. BoNT-A naïve) were noted: (rotational torticollis: 73% vs. 64%; laterocollis 19% vs. 26%; retrocollis 4% vs. 6%; other patterns <3% of patients). Previously treated patients had received a median of 8 (range 1-99) injection cycles; median time since their first BoNT-A injection was 44.7 (range 2-280) months. Overall, 60% patients had previously been treated with abobotulinumtoxinA, Dysport® (median dose 500 U), 37% with OnabotulinumtoxinA, Botox® (190 U) and 3% with IncobotulinumtoxinA, Xeomin® (150 U). BoNT-A naïve patients trended towards having higher TWSTRS total (mean±SD) (38.4±12.4 vs. 34.5±11.7), disability (11.7±6.6 vs. 9.8±6.0) and pain scores (8.9±5.1 vs. 6.6±5.0) at baseline. TWSTRS severity scores (mean±SD) were similar (17.9±5.0 vs. 18.0±4.7, respectively for BoNT-A naïve and previously treated patients). When compared to previously treated CD patients, ‘new’ patients presenting for treatment with BoNT-A tend to have higher levels of pain and disability. This suggests that continued treatment reduces the severity of CD pain and disability or that the therapeutic effects of their prior injection series has not yet worn off and the benefits of BoNT-A may last longer than patients perceive.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".