The effects of altered expression of the <scp>K</scp> eap1/ <scp>CncC</scp> pathway on the secretion of fluid and salicylate by <scp>M</scp> alpighian tubules of <i> <scp>D</scp> rosophila melanogaster </i>
Bibliographic record
Abstract
Abstract The K eap1‐ N rf2 pathway is a major upstream regulator of xenobiotic detoxification. In D rosophila melanogaster M eigen, targeted expression of K eap1 and CncC (the latter the orthologue of human N rf2) in the M alpighian (renal) tubules is known to confer resistance to lethal doses of the pesticide malathion, which is metabolized into organic anions. Dietary exposure to organic anions such as salicylate (10 m m ) causes increases in the fluid secretion rate and salicylate flux across M alpighian tubules. In the present study, salicylate‐selective microelectrodes and R amsay assays are used to determine the role of K eap1/ N rf2 in regulating these responses. Genetic manipulations designed to increase N rf2 activity (by knockdown of the repressor K eap1 or overexpression of the N rf2 coactivator MafS ) or to decrease N rf2 activity (by overexpression of K eap1) are also studied. Although the results of the K eap1 manipulations are inconclusive, there is no increase in the fluid secretion rate or salicylate flux in tubules isolated from flies in which MafS expression is increased.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.005 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".