Effect of Curcumin Supplementation on Physiologic Response and Recovery Following Repeated Stressful Exercise
Bibliographic record
Abstract
Curcumin is a powerful anti-inflammatory, antioxidant and scavenger of reactive oxygen/nitrogen species. Curcumin supplementation has been suggested to acutely blunt delayed onset muscle soreness (DOMS), while reducing inflammation. PURPOSE: To determine if sub-acute curcumin supplementation between repeated downhill runs alters human adaptation to exercise induced stress and muscle damage considering cardiovascular and muscular variables. METHODS: Twenty-one (11m/10f) recreationally active volunteers (24.1±6.2yr, 48.9±7.6 ml/kg/min) completed 2 downhill runs (60% VO2max, -12° grade). At baseline, then 24h, 48h, and 72h post exercise, measures of muscle damage (CK), DOMS (1000p visual analogue scale), inflammation (hs-CRP, IL-6), blood pressure, vascular stiffness (PWV), and reactive hyperemia (RHI) were taken. The procedure was repeated for phase 2, using a double blind allocation for supplementation with either 200mg curcuminoids (CUR) or a placebo (PLA) for 7d. RESULTS:DOMS and CK levels were elevated following downhill run 1 in both groups (p<0.001). At the initiation of run 2, CK levels had returned to baseline in the CUR group, but not the PLA (p<0.05). Following run 2 the CK response was blunted in the CUR group ((304± 81 vs 197±86, p=0.02), but not PLA, and peak DOMS was higher in the CUR group versus the control at 24h (PLA 170±129 CUR 322±188, p=0.046) and 48h (PLA 245±147; CUR 476±228, p=0.01). No significant alterations were observed for any cardiovascular indices including blood pressure, PWV, or RHI following run 1 or 2. Non-significant elevations (p<0.06) were observed for hs-CRP and IL-6, with no difference following supplementation. CONCLUSIONS: The sub-acute use of curcumin for 7d after the first 72hr of recovery affected physiological response and perceived pain resulting from a repeated downhill run 1 week following the first. Decreases in creatine kinase (CK) suggest supplementation was effective for altering delayed recovery properties, as well as peak damage. DOMS revealed curcumin supplementation between bouts led to a greater level of discomfort following the second exposure. This may be indicative of alterations to the natural adaptive process and could have implications for repeated training.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".