Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents
Why this work is in the frame
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Bibliographic record
Abstract
Dendronized carborane containing polymers were successfully synthesized by the "graft-from" approach using a divergent dendron growth up to the fourth generation. Nitroxide mediated polymerization (NMP) proved effective in polymerizing the carborane-functionalized styrenic monomer to produce a well defined polymer with high boron content (~26% B by weight) and narrow polydispersity index (PDI < 1.1). Dendronization of the carborane functionalized polymer was achieved via deprotonation of the acidic carborane proton in the para position followed by reaction of the polyanion with a benzylidene protected bisMPA anhydride. Complete removal of the benzylidene protecting group was achieved by a combination of Pd-catalyzed hydrogenolysis and acid-catalyzed deprotection. This chemistry proved effective in the preparation of monodisperse, high-generation hydroxyl-terminated dendrons appended to the carborane-functionalized polymer backbone. The fourth generation polymer, [G-4]-(OH)16, having a molecular weight of 114 kDa, was found to be water soluble at a concentration of 1 mg/mL and afforded a B content of approximately 12% by weight. All of the products were characterized by NMR and SEC.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it