Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents
Bibliographic record
Abstract
Dendronized carborane containing polymers were successfully synthesized by the "graft-from" approach using a divergent dendron growth up to the fourth generation. Nitroxide mediated polymerization (NMP) proved effective in polymerizing the carborane-functionalized styrenic monomer to produce a well defined polymer with high boron content (~26% B by weight) and narrow polydispersity index (PDI < 1.1). Dendronization of the carborane functionalized polymer was achieved via deprotonation of the acidic carborane proton in the para position followed by reaction of the polyanion with a benzylidene protected bisMPA anhydride. Complete removal of the benzylidene protecting group was achieved by a combination of Pd-catalyzed hydrogenolysis and acid-catalyzed deprotection. This chemistry proved effective in the preparation of monodisperse, high-generation hydroxyl-terminated dendrons appended to the carborane-functionalized polymer backbone. The fourth generation polymer, [G-4]-(OH) 16, having a molecular weight of 114 kDa, was found to be water soluble at a concentration of 1 mg/mL and afforded a B content of approximately 12% by weight. All of the products were characterized by NMR and SEC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".