Record W2475552772 · doi:10.1186/s12864-016-2858-0

Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)

2016· article· en· W2475552772 on OpenAlexaff

Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Nobutaka Hirokawa, Maryam Goudarzi, Albert J. Fornace, Saleh Baeesa, Deema Hussain, Fahad Alghamdi, Hans-Juergen Schulten, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder Singh Saini, Awatif Jamal, Mohammed Al‐Qahtani, Ghazi Damanhouri, Heba Alkhatabi, Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp, Jim Vaught, Bruce Budowle, Abdelbaset Buhmeida, Leena Merdad, Sudhir Kumar, Sayaka Miura, Karen Gomez, Elham Alhathli, Nada Salem, H. M. Faheem, Ashok Agarwa, Eberhard Nieschlag, Joachim Wistuba, Oliver Damm, Taha Abo-Almagd Abdel-Meguid Hamoda, Hisham A. Mosli, Osama S. Bajouh, Serdar Coşkun, Ashraf Dallol, Wejdan Al-Qahtani, Asia Al-Harbi, Burak Özkösem, Rick DuBois, Maryam T. Dandana, Wassim Y. Almawi, S. Abdalla, M. Nabil Al-Aama, Asmaa Elzawahry, Tsuyoshi Takahashi, Sachiyo Mimaki, Eisaku Furukawa, Rie Nakatsuka, Isao Kurosaka, Takahiko Nishigaki, Hiromi Nakamura, Satoshi Serada, Tetsuji Naka, Seiichi Hirota, Tatsuhiro Shibata, Katsuya Tsuchihara, Toshirou Nishida, Mamoru Kato, Sajid Mehmood, Naeem Mahmood Ashraf, Awais Asif, Muhammad Bilal, Malik Siddique Mehmood, Aadil Hussain, Qazi Mohammad Sajid Jamal, Mughees Uddin Siddiqui, Mohammad A. Alzohairy, Mohammad A. Al Karaawi, Taoufik Nedjadi, Heba Al-Khattabi, Ahmed Al-Sayyad, Mohammed Al-Qahtani, Hédia Zitouni, Nozha Raguema, Marwa Ben Ali, Wided Malah, Raja Lfalah, Touhami Mahjoub, Mohammed Elanbari, Andrey Ptitsyn, Sana Mahjoub, Rabeb El Ghali, Béchir Achour, Nidhal Ben Amor, B Nsiri, Hamid Morjani, Esam I. Azhar, Vera Chayeb, Maryam Dendena, Khedija Zouari-Limayem, Bassem Refaat, Ahmad Mohammad Ashshi, Sarah Abdullah Batwa, Hazem Ramadan, Amal Awad, Ahmed Ateya, Adel Galal El-Shemi, Mohammad A. BaSalamah, Youjin Na, Chae‐Ok Yun, Osama A. Kensara, A. M. ABDEL‐FATTAH, Batol Imran Dheeb, Mohammed M. F. Al-Halbosiy, Rghad Kadhim Al lihabi, Basim Mohammed Khashman, Djouhri Laiche, Chaudhary Adeel, Hani Al-Afghani, Maria Łastowska, Haya H. Al‐Balool, Harsh Sheth, Emma Mercer, Jonathan Coxhead, Christopher P.F. Redfern, Heiko Peters, Alastair D. Burt, Mauro Santibanez‐Koref, Chris M. Bacon, Louis Chesler, Alistair G. Rust, David J. Adams, Daniel Williamson, Steven C. Clifford, Michael S. Jackson, Mala Singh, Mohmmad Shoab Mansuri, Shahnawaz D. Jadeja, Hima Patel, Yogesh Marfatia, Rasheedunnisa Begum, Amal M. Mohamed, Alaa K. Kamel, Nivin A. Helmy, Sayda A. Hammad, Hesham F. Kayed, Marwa Shehab, Assad El Gerzawy, Maha M. Ead, Ola M. Ead, Mona K. Mekkawy, Innas Mazen, Mona El‐Ruby, Sara Shahid, Jamal M. Arif, Mohtashim Lohani, Imen Moumni, Leila Chaouch, Houyem Ouragini, Kaïs Douzi, Chaouachi Dorra Mellouli Fethi, Bejaoui Mohamed, Salem Abbes, Areeg Faggad, Amanuel Tsegai Gebreslasie, Hani Y. Zaki, Badreldin Elsonni Abdalla, Maha S. Al-Shammari, Rhaya Al-Ali, Nader Mousa Rubayyi Albalawi, Mansour S. Al-Enazi, Ali A. Al-Muraikhi, Fadi Busaleh, Ali S. Al-Sahwan, J. Francis Borgio, Amein K. Al‐Ali, Sadananda Acharya, Maha S. Zaki, Hala T. El‐Bassyouni, Mohamed F. Elshal, Kaleemuddin Mohammed, Alia Aldahlawi, Omar I. Saadah, J. Philip McCoy, Adel E. El-Tarras, Nabil S. Awad, Abdulla A. Alharthi, Mohamed M. M. Ibrahim, Haneen Alsehli, Abdullah Gari, Roaa Kadam, Mazen M. Gari, Mohmmed H. Alkaff, Adel Abuzenadah, Mamdooh Gari, Fatima A. Moradi, Omran M. Rashidi, Zuhier Awan, Ibrahim H. Kaya, Olfat Al‐Harazi, Dilek Çolak, Nabila A. Alkousi, Takis Athanasopoulos, Afnan Omar Bahmaid, Etimad A. Alhwait, Mohammed Abbas, Salma N. Alsayed, Fawziah H. Aljohani, Samaher M. Habeeb, Rawan A. Almashali, Sulman Basit, Samia M. Ahmed, Rakesh Sharma, Ashok Agarwal, Luna Samanta, Muhammad Abu-Elmagd, Edmund S. Sabanegh, Zhihong Cui, Alaa A. Al-boogmi, Nuha A. Alansari, Maha M. Al-Quaiti, Fai T. Ashgan, Hasan Salleh Jamal, Abdullraheem Rozi, Zeenat Mirza, Ahmad J. Al Sayyad, Jaudah Al‐Maghrabi, Alaa Alahmadi, Rasha A. Ebiya, Samia M. Darwish, Metwally M. Montaser, Heba Abusamra, Vladimir B. Bajić, Wafaey Gomaa, Mehenaz Hanbazazh, Mahmoud Al-Ahwal, Saher Hakamy, Ghali Baba, Abdullah Abdulkarim Ali Al-Harbi, Ghalia Baba, Hend Nour Eldin, Aisha Alyamani, Mohammed H. Alkaf, Rawan Gadi, Saadiah M. Alfakeeh, Ghazala Rubi, M. Haroon Hamed, Ishtiaq Qadri, Manal Shaabad, Shilu Mathew, Shireen Hussain, Mikhlid H. Almutairi, Angie Ambers, Jennifer D. Churchill, Jonathan L. King, Monika Stoljarova, Harrell Gill-King, Muhammad Al-Qatani, Taha Abo Almagd, Muhammad Hussain Al-Qahtani, Abdelbaset Buhmaida, Afnan Bandah, Rukhsana Satar, Mahmood Rasool, Nazia Nazam, Mohamad I. Lone, Syed Kashif Zaidi, Peter Natesan Pushparaj, Hanan Bashier, Abrar Al Qahtani, Amal M. Nour, Adel M. Abu Zenadah, Muhammed Al Qahtani, Muhammad Faheem, Shiny Mathew, Hani A. Alhadrami, Ibtessam R. Hussein, Rima S. Bader, Randa Bassiouni, Mohamed N. Alama, Mohammad H. Al Qahtani, Nazia Nizam, Shakeel Ahmed Ansari, Muhammed Al-Qahtani, Eradah Alshihri, Lina Alharbi, Peter Pushparaj Natesan, Fazal Khan, Khalid Sait, Nisreen Anfinan, Lobna S. Mira, Adeel Chaudhary, Sameera Sogaty, Mohammad Sarwar Jamal, Abdulrahman M. S. Sibiani, Mohammad Jafri, Muhammad I. Naseer, Mohammed Al-Qahtani, Kundan Kumar, Ahmad Abu Turab Naqvi, Faizan Ahmad, Md. Imtaiyaz Hassan, Jummanah Jarullah, Abdelbasit Buhmeida, Shahida Khan, Ghufrana Abdussami, Maryam Mahfooz, Mohammad Amjad Kamal, Mohammad S. S. Jarullah, Muhammad Abu‐Elmagd, Abdulah E. A. Mathkoor, Hashim M. A. Alsalmi, Anas M. M. Oun, Ghazi A. Damanhauri, Yousif Ahmed Abutalib, Daniele Merico, Susan Walker, Christian R. Marshall, Mehdi Zarrei, Stephen W. Scherer, Mohammad H. Al-Qahtani, Mohammed M. Jan, Maryam H. Al-Zahrani, Sahira Lary, Emmanuel Dermitzakis, Abeer Ahmed ALrefai, Mona Saleh, Rehab I. Yassien, Mahmmoud Kamel, Rabab M. Habeb, Najlaa Filimban, Nadia Ghannam, Fehmida Bibi, Sana Akhtar, Muhammad Yasir, Muhammad I. Nasser, Asif A. Jiman-Fatani, Ali Sawan, Ruaa A. Lahzah, Asho Ali, Seyed E. Hasnain, Iftikhar Aslam Tayubi, Hamza A. S. Abujabal, Alaa O. Magrabi, Adel Abuzenada, Taha A. Kumosani, Elie K. Barbour, Manal Shabaad, Adnan Merdad, Kalamegam Gauthaman, Hani Moaiteq Aljahdali, Reham Al Nono, Mohammed Sarwar Jamal, Mansour A. Alghamdi, Magdy Shamy, Max Costa, Mamdouh I. Khoder, Najla Kharrat, Sabrine Belmabrouk, Rania Abdelhédi, Riadh Benmarzoug, Ahmed Rebaï, Ghazi Dhamanhouri, Abdelwahab Noorwali, Afnan Bahamaid, Ali Mobasheri, Muhammad Faheem, Raziuddin Khan, Kanchan Bhatia, Iftikhar AslamTayubi, Manish Tripathi, Syed Asif Hassan, Rahul Shrivastava, Syed Shah Hassan, Ishani Shah, Ishfaq A. Sheikh, Ejaz Ahmad, Mohd Rehan, Samera F. AlBasri, Rola Turki, Ghazi A. Damanhouri, M.A. Beg, Sahar AF. Hammoudah, Khalid M. Al-Harbi, Lama M. El-Attar, Ahmed M. Z. Darwish, Sara M. Ibrahim, Hani Choudhry, Jalaludden Awlia, Farid Ahmed, Imran khan, Sameera F.M. AlBasri, Heba M. EL Sayed, Eman Abdel Razek Hafez, Aisha Elaimi, Mohammad Khalid Alwasiyah, Richard F. Wintle, Vikram Gopalakrishna Pillai, Sujata Sharma, Punit Kaur, Alagiri Srinivasan, T.P. Singh, Reem Alotibi, Deema Hussein, Mona Al‐Sharif, Mohammed Bangash, Taha Kumosani, Faisal A. Al-Allaf, Zainularifeen Abduljaleel, Abdullah Al‐Ashwal, Mohiuddin M. Taher, Abdellatif Bouazzaoui, Halah Abalkhail, Faisal A. Ba-Hammam, Mohammad Athar, Khalid HussainWali Sait, Naira Ben Mami, Yosr Z. Haffani, M Medhioub, Lamine Hamzaoui, Ameur Cherif, Msadok Azouz, Mohammed Nasser, Shereen A. Turkistany, Jamal S. M. Sabir, Basmah Al-Madoudi, Bayan Al-Aslani, Khawlah Alharbi, Rwan Al-Jahdali, Hanadi Qudaih, Emad Al Hamzy, Asad Muhammad Ilyas, Youssri Ahmed, Mohammed Hussein Al-Qahtani, Alaa Alamandi, Ohoud Subhi, Adel Al-Johari, Osman Abdel Al-Hamour, Hosam Al-Aradati, Abdulmonem Almutawa, Faisal Al-Mashat, Sajjad Karim, Mohammad Al-Qahtani, Muhammad Waseem Shah, Saad Al-Masoodi, Emna Khamla, Chaima Jlassi, Ahmed S. Masmoudi, Lassaâd Belbahri, Shadi Alkhayyat, Roba Attas, Atlal Abusanad, Mohammed F. Abuzinadah, Habib Bouazzi, Carlos Trujillo, Maha Alotaibi, Rami Nassir, Essam H. Jiffri, Ghulam Md Ashraf, Mohammad Azhar Aziz, Rizwan Ali, N Samman, Sathish Periyasamy, Mohammed Aldress, Majed Al Otaibi, Zeyad Al Yousef, Mohamed Boudjelal, Ibrahim AlAbdulkarim, Mohd Suhail, Abid Qureshi, Adil Jamal, Mahmoud Zaki El-Readi, Safaa Yehia Eid, Michaël Wink, Ahmed M. Isa, Lulu Al‐Nuaim, Johara Al-Mutawa, Basim Abu-Rafae, Saleh AlAsiri, Saleh Binsaleh, Waseem Ahmad, Mohamed H. Alqahtani

Bibliographic record

VenueBMC Genomics · 2016

Typearticle

Languageen

FieldBiochemistry, Genetics and Molecular Biology

TopicEpigenetics and DNA Methylation

Canadian institutionsUniversity of TorontoSickKids FoundationHospital for Sick Children

FundersNational Plan for Science, Technology and InnovationMedical Research CouncilAll-India Institute of Medical SciencesKing Abdulaziz City for Science and TechnologyInstitut Pasteur de TunisKing Abdulaziz UniversityIndian Council of Medical Research

KeywordsBiologyGeneticsLibrary scienceBioinformatics

DOI10.1186/s12864-016-2858-0

Abstract

fetched live from OpenAlex

The ends of linear chromosomes are called telomeres that resemble broken DNA.However, the telomeres are protected from the DNA damage responses due to the formation of a looping structure (Tloop) and by "capping" the telomeres with a series of shelterin proteins.It is generally thought the main, if not only, function of telomeres is protection from DNA damage responses.When telomeres get very short due to normal replicative aging, cells stop dividing due to loss of the telomere end protective functions.We have previously reported that telomeres may also have additional functions in human cells.Telomeres are characterized by a distinct chromatin structure with spreading of heterochromatin into the subtelomeric regions, but little is known about the chromatin conformation of human telomeres.We have previously shown, using a luciferase reporter introduced into telomeres, that there is a 10-fold decreased expression of the reporter compared to the reporter introduced into internal genomic loci.This phenomenon is known as Telomere Position Effects (TPE).We have also found that a human gene, interferon stimulating gene 15 (ISG15), (~1 M base pairs from the 1p36.33 telomere) is silenced in young cells with long telomerase, upregulated in cells with short telomeres and silenced again in old cells with experimentally hTERT (telomerase) elongated telomeres.However, we observed genes between ISG15 and the telomere are not regulated by classic telomere position effects (TPE).To distinguish this type of telomere length dependent regulation of gene expression from classic TPE, we have termed this type of regulation Telomere Position Effects Over Long Distances (TPE-OLD).We discovered using 3D co-FISH and a modification of Hi-C (chromosome capture followed by high-throughput sequencing), that there are a significant number of genes within the first 10 M bases distal to the telomere on many chromosomes regulated by telomere length with genes closer to the telomere not being regulated by TPE.O2

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002

metaresearch head score (Gemma)0.003

Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Not applicable · Consensus signal: Not applicable

GenreCandidate signal: Other · Consensus signal: none

Teacher disagreement score0.236

Threshold uncertainty score0.790

Distilled classifier scores by category (both heads)

Category	Codex	Gemma
Metaresearch	0.002	0.003
Meta-epidemiology (narrow)	0.001	0.000
Meta-epidemiology (broad)	0.001	0.001
Bibliometrics	0.002	0.001
Science and technology studies	0.001	0.000
Scholarly communication	0.003	0.001
Open science	0.001	0.003
Research integrity	0.002	0.002
Insufficient payload (model declined to judge)	0.236	0.126

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029

GPT teacher head0.274

Teacher spread0.246 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designNot applicable

Domainnot available

GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations28

Published2016

Admission routes1

Has abstractyes

Download record (JSON)Report an issue with this record

Explore more

Same venueBMC Genomics→Same topicEpigenetics and DNA Methylation→French-language works237,207→