[OP.LB03.03] THE RELATIONSHIP BETWEEN DIASTOLIC FUNCTION AND CENTRAL HEMODYNAMICS IN DIABETIC HYPERTENSIVE PATIENTS
Bibliographic record
Abstract
Objective: Diabetic hypertensives patients present different hemodynamic pattern than only hypertensive patients. We aimed to investigate the relationship between the diastolic function and the pulse pressure amplification (PPA), an index combining both arterial stiffness and wave reflexion, in diabetic hypertensives subjects compared to hypertensive subjects.Design and method: We examined 123 patients admitted to the one day hospital of the Hotel-Dieu Hospital (Paris, France) for cardiovascular risk assessment. Anthropometric, laboratory and clinical measurements were collected. Hemodynamic parameters (central blood pressure, aortic pulse wave velocity [PWV], augmentation index [AIx] and PPA) were measured using applanation tonometry. Standard ultrasound echocardiography was performed. Results: Diabetic hypertensive subjects (n = 44) were older than hypertensive subjects (n = 79)(mean age[SD] 64[9] vs 56[14], p < 0.05), and they presented similar cardiovascular risk factors frequencies. Gender was equally distributed. The diastolic function, assessed by the E/E′ ratio was significantly positively correlated with PWV in total population (r = 0.19, p = 0.03), with no differences between the two groups. At the contrary, as shown in the figure, E/E′ ratio was not correlated with PPA in total population, but it was significantly and negatively correlated with PPA only in the diabetic group (p for interaction 0.007, r = - 0.35, p = 0.02). The multiregression analysis (containing all the confounding variables) in this group revealed as significant (p value < 0.05) determinants of PPA: the diastolic function (partial-R2 = 0.14), gender (partial-R2 = 0.27), heart rate (partial-R2 = 0.26), angiotensin blockers treatement (partial-R2 = 0.13). Conclusions: We confirmed that diabetic hypertensive patients have different hemodynamic behaviour than hypertensive non-diabetic patients. The results suggest that the mechanisms linking diastolic function with PPA are more prominent in diabetic patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.447 | 0.197 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".