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Record W2486459251 · doi:10.1385/0-89603-510-7:103

Neural Cell Adhesion Molecules

2003· book-chapter· en· W2486459251 on OpenAlexaff
Kim Tieu, Peter H. Yu

Bibliographic record

VenueHumana Press eBooks · 2003
Typebook-chapter
Languageen
FieldNeuroscience
TopicAxon Guidance and Neuronal Signaling
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsBiologyNervous systemZebrafishEmbryonic stem cellCell adhesion moleculeCell adhesionCell biologyAdhesionCell typeEmbryoNeural cell adhesion moleculeCellNeuroscienceChemistryBiochemistry

Abstract

fetched live from OpenAlex

During development of the nervous system, cell migration, axonal outgrowth, axonal guidance, and selective cell adhesion and recognition are some of the crucial processes required for neural pattern formation. Numerous studies reveal that cells bind selectively to one another and that they segregate according to their tissue types. As early as 1907, Wilson demonstrated that dissociated cells from two different types of sponges, when mixed together, reassociated to form two organisms, each containing cells from one parent species. Similar results are also observed in coelenterates (Chalkey, 1945), chick embryonic cells (Moscona and Moscona, 1952) and amphibian embryonic cells (Holtfreter 1948a,b; Townes and Holtfreter, 1955). When the nervous system is in its developmental stages, neurons extend their axons over considerable distances to innervate their targets. Studies done in grasshopper (Bastiani et al, 1986; Bastiani and Goodman, 1986; du-Lac et al, 1986), zebrafish embryo (Kuwada, 1986,1992), and chick retinal ganglion cells (Silver and Sapiro, 1981) indicate that these connectivities are carried out in a highly stereospecific fashion. There are many theories regarding these selective interactions, and cell adhesion molecules have been shown to play a very significant role.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.661
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.117
GPT teacher head0.270
Teacher spread0.153 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2003
Admission routes1
Has abstractyes

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