Synthesis and Evaluation of Hydrophobically-Modified Polysaccharides as Oral Delivery Vehicles for Poorly Water-Soluble Drugs
Bibliographic record
Abstract
Novel polysaccharide-based micelles were prepared to exploit their potential towards solubilizing poorly water-soluble drugs in order to improve their oral bioavailability. Hydrophobically-modified (HM) dextran (DEX) and hydroxypropylcellulose (HPC) copolymers were synthesized. Cyclosporine A (CsA) was selected as a model drug. In aqueous solution, HM-DEX and HM-HPC form polymeric micelles with low onset of micellization. The CsA incorporation in HM-polysaccharide micelles was significantly higher than in corresponding unmodified polysaccharides. The polymeric micelles exhibited no significant cytotoxicity towards Caco-2 cells at concentrations up to 10 g/L. The apical to basal permeability of CsA across Caco-2 cells increased significantly, when loaded in polymeric micelles, compared to free CsA.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".