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Record W2498524960 · doi:10.1016/j.radonc.2016.06.017

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

2016· review· en· W2498524960 on OpenAlexaff
Christian Nicolaj Andreassen, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Dirk De Ruysscher, Jamie A. Cesaretti, Gillian C. Barnett, Alison M. Dunning, Leila Dorling, Catharine West, N.G. Burnet, Rebecca Elliott, Charlotte E. Coles, Emma Hall, Laura Fachal, Ana Vega, Antonio Gómez‐Caamaño, Chris J. Talbot, R.P. Symonds, Kim De Ruyck, Hubert Thierens, Piet Ost, Jenny Chang‐Claude, Petra Seibold, Odilia Popanda, Marie Overgaard, David P. Dearnaley, Matthew R. Sydes, D. Azria, Christine Koch, Matthew Parliament, Michael Blackshaw, Michael Sia, M.J. Fuentes-Raspall, Teresa Ramón y Cajal, Agustín Barnadas, Danny Vesprini, Sara Gutiérrez‐Enríquez, Meritxell Mollà, Orland Dı́ez, J. Yarnold, Jens Overgaard, Søren M. Bentzen, Jan Alsner

Bibliographic record

VenueRadiotherapy and Oncology · 2016
Typereview
Languageen
FieldMedicine
TopicEffects of Radiation Exposure
Canadian institutionsSunnybrook Health Science CentrePrincess Margaret Cancer CentreBC Cancer AgencyUniversity of AlbertaHealth Sciences CentreUniversity Health Network
FundersEuropean Social FundU.S. Department of DefenseEuropean Regional Development FundMedical Research CouncilXunta de GaliciaInstituto de Salud Carlos IIICancer Research UKAmerican Cancer SocietyNational Institute for Health and Care ResearchKræftens BekæmpelseNational Cancer InstituteNational Institutes of Health
KeywordsProstate cancerOncologyMedicineMeta-analysisRadiation therapyBreast cancerInternal medicineSNPAssociation (psychology)ToxicityCancerSingle-nucleotide polymorphismPsychologyBiologyGenotypePsychotherapist

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.007
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0050.018
Bibliometrics0.0010.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.060
GPT teacher head0.370
Teacher spread0.310 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations152
Published2016
Admission routes1
Has abstractno

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