MétaCan
Menu
Back to cohort
Record W2498618443 · doi:10.1385/0-89603-077-6:1

Automated Amino Acid Analysis

2003· book-chapter· en· W2498618443 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueAmino Acids · 2003
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBiopolymer Synthesis and Applications
Canadian institutionsBC Children's Hospital
Fundersnot available
KeywordsNinhydrinAmino acidReagentChemistryChromatographyPaper chromatographyHydrolysisAmino acid analysisAcid hydrolysisElutionOrganic chemistryBiochemistry

Abstract

fetched live from OpenAlex

Knowledge of the existence of amino acids dates back over a century in many cases, as does knowledge of their existence in proteins (see ). When amino acids were discovered, their identity was established by isolating and purifying the individual compounds and obtaining elemental analyses After the advent of paper chromatography, this technique was used with a variety of different solvents to identify elution characteristics and demonstrate the purity of isolated compounds. Amino acids were located by the use of a reagent that produced a color with the compound. The most common reagent used for locating amino acids is ninhydrin, which produces a purple color with amino acids, a pink or yellor color with amino acids, and various intermediate colors with compounds containing an amino group and a sulfonic acid, and so on. It also reacts with small peptides such as glutathione. The techniques of paper chromatography were applied to the separation of mixtures of amino acids, such as the components of a protein after hydrolysis, and then to the separation of free amino acids in physiologic fluids and tissues. It was extended by the use of two-dimensional chromatography, in which a different solvent was used in each direction Later, electrophoresis was employed as one of the separating techniques

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.649
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.240
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it