Knowledge-Based Induction of Clinical Prediction Rules
Bibliographic record
Abstract
This chapter describes how to integrate medical knowledge with purely inductive (data-driven) methods for the creation of clinical prediction rules. It addresses three issues: representation of medical knowledge, secondary analysis of medical data, and evaluation of automatically induced predictive models in the context of existing knowledge. To address the complexity of the domain knowledge, the authors have introduced a semio-fuzzy framework, which has its theoretical foundations in semiotics and fuzzy logic. This integrative framework has been applied to the creation of clinical prediction rules for the diagnosis of obstructive sleep apnea, a serious and under-diagnosed respiratory disorder. The authors use a semio-fuzzy approach (1) to construct a knowledge base for the definition of diagnostic criteria, predictors, and existing prediction rules; (2) to describe and analyze data sets used in the data mining process; and (3) to interpret the induced models in terms of confirmation, contradiction, and contribution to existing knowledge.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".