B-005SURGICAL THERAPY OF THYMIC TUMOURS WITH PLEURAL INVOLVEMENT: AN ESTS THYMIC WORKING GROUP SURVEY
Bibliographic record
Abstract
Objectives: The value of surgical therapy for primary or recurrent thymic tumours with pleural involvement is not sufficiently defined yet. The ESTS Thymic Working Group collected retrospective data on patients undergoing surgery for primary and recurrent thymic tumours with pleural involvement. Methods: A detailed questionnaire comprising all relevant clinical data was sent out to the members of the ESTS Thymic Working Group. Twelve institutions from eight countries contributed their data. Results: From 1977 to 2014, 152 patients (50% females) underwent different surgical procedures. In 70.4% cases pleural involvement was present at the time of primary intervention. The other 29.6% of cases had surgery for recurrent disease involving the pleura. Pleural involvement resulted from thymoma (89.5%) and thymic carcinoma (TC: 10.5%). Type of operation was extrapleural pneumonectomy (EPP): 40, total pleurectomy (TP): 23 (including 4 cases of pleurectomy/decortication), local pleurectomy (LP): 88, and pericardial resection in 52 patients. The median follow-up time for the entire patient cohort was 52 months [range 0-265]. Overall survival (OS) for the entire patient population at 1-, 3-, 5-, and 10-years was 96.4%, 91.0%, 87.2% and 62.7%. Patients with thymomas showed significantly better 10-year OS than TC (P < 0.001; TC median114 months, thymomas: not reached). The 1-, 3-, 5, and 10-year OS after EPP was 88.6%, 85.5%, 80.1% and 40.1%; after TP: 94.4%, 85.9%, 85.9% (follow-up 10-years not reached) and after LP: 100%, 94.4%, 90.6% and 72.2%, respectively (P = 0.067). Fifty-three percent of patients developed recurrence after pleural surgery after a median of 46 months (local: 22.2%, regional: 51.9%, distant: 13.6%, regional and distant: 9.9%, local and regional: 1.2%, missing data: 1.2%). There was no statistically significant difference regarding freedom from recurrence for patients with local or advanced disease undergoing EPP (median 31 months), or TP (median 69 months) or LP (median 46 months; P = 0.266). Completeness of resection (R0) was achieved in 76.8% of cases (EPP: 95%, TP: 60.9%, LP: 72.7%). OS was better after complete resection (R0: median survival unreached) compared to incomplete resection (R1 + R2: 105 months; P < 0.001). Conclusion: Surgical therapy of thymic tumours with pleural involvement is infrequently performed. Different treatment modalities: EPP, TP and LP yield excellent results regarding OS and freedom-from-recurrence. Prospectively collected data on all patients with thymic tumours and pleural involvement are warranted. Disclosure: No significant relationships.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".