229: Improved Disease-Free Survival with Adjuvant Radiation Therapy (RT) in Patients with Stage IIIC2 Endometrial Carcinoma – Experience From Two Provinces
Bibliographic record
Abstract
Purpose: Recent sequencing efforts have allowed for the molecular taxonomy of prostate cancer (TCGA, 2015).In a subset of patients, mutations and copy-number losses in the homologous recombination pathway were found.The TONSL-MMS22L complex has recently been shown to be involved in the recovery from replication stress through homologous recombination (Duro et al, 2010; O'Donnell et al, 2010).It physically associates with BRCA1/2, RAD51, and RPA.Our study sought to correlate TONSL complex expression with biochemical relapse in prostate cancer patients Methods and Materials: Our cohort consists of 250 patients with D'Amico-classified intermediate-risk prostate cancer, treated with image-guided radiotherapy (IGRT, n = 116) or radical prostatectomy (RadP, n = 134).Pre-treatment biopsies were analyzed using the Affymetrix Oncoscan array.The Phoenix and AUA criteria was used to define biochemical relapse for RadP and IGRT patients respectively.mRNA expression data was taken from the TCGA Provisional cohort using cBioPortal (Gao et al., 2013). Results:Copy number alterations of TONSL and MMS22L were observed in 31% (n = 78) and 20% (n = 51) of our cohort respectively.They were predominantly gains in TONSL, but losses in MMS22L.TONSL amplification, but not MMS22L, was significantly associated with biochemical recurrence (Chi-square = 12, p < 0.001).TONSL remained significantly associated on multivariate analysis, controlling for tumour stage, Gleason score, and PSA (p < 0.005).In the TCGA cohort, over-expression of TONSL (p < 0.005) as well as other members of the homologous recombination pathway (e.g.RAD51D, BRCA1, XRCC2, POLD1, TOP3A, etc.) were associated with disease recurrence (p < 0.001). Conclusions:We identified a novel association of copy-number gain and over-expression of TONSL with biochemical recurrence following radical prostatectomy or image-guided radiotherapy.This points to a potential gene dosage effect and the central role of the homologous recombination pathway in prostate cancer progression.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".