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Record W2512442926 · doi:10.1038/nchembio.2166

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

2016· article· en· W2512442926 on OpenAlexfundno aff
Tinghu Zhang, Nicholas Kwiatkowski, Sarah E. Dixon-Clarke, Brian J. Abraham, Ann Katrin Greifenberg, Scott B. Ficarro, Jonathan M. Elkins, Yanke Liang, Nancy M. Hannett, Theresa Manz, Mingfeng Hao, Bartlomiej Bartkowiak, Arno L. Greenleaf, Jarrod A. Marto, Matthias Geyer, Alex N. Bullock, Richard A. Young, Nathanael S. Gray

Bibliographic record

VenueNature Chemical Biology · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicProtein Degradation and Inhibitors
Canadian institutionsnot available
FundersNational Cancer InstituteMedical Research CouncilMinistero dello Sviluppo EconomicoOntario Genomics InstituteHope Funds for Cancer ResearchDiamond Light SourceNational Human Genome Research InstituteWellcome TrustNational Institutes of HealthOntario GenomicsGenome CanadaOntario Ministry of Economic Development and InnovationKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDeutsche ForschungsgemeinschaftDana-Farber/Harvard Cancer CenterGlaxoSmithKlinePfizerEli Lilly and Company
KeywordsKinaseEnhancerCell biologyBiologyTranscription factorCyclin-dependent kinaseProcessivityGene expressionTranscription (linguistics)GeneChemistryMolecular biologyGeneticsPolymeraseCell cycle

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.252
Teacher spread0.247 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations372
Published2016
Admission routes1
Has abstractno

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Same venueNature Chemical BiologySame topicProtein Degradation and InhibitorsFrench-language works237,207