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Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

2016· article· en· 1,292 citations· W2514448720 on OpenAlex· 10.1038/ng.3646

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.021
GPT teacher head0.290
Teacher spread
0.270 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Genetics
Topic
Acute Myeloid Leukemia Research
Field
Medicine
Canadian institutions
Princess Margaret Cancer CentreUniversity Health Network
Funders
U.S. National Library of MedicineNational Cancer InstituteNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Human Genome Research InstituteHoward Hughes Medical Institute
Keywords
BiologyChromatinHaematopoiesisStem cellLineage (genetic)GeneticsHematopoietic stem cellLeukemiaComputational biologyEnhancerMyeloidEpigenomicsCancer researchGeneTranscription factorDNA methylationGene expression
Has abstract in OpenAlex
no