Serotonin transporter binding is reduced in seasonal affective disorder following light therapy
Bibliographic record
Abstract
Objective To investigate the effects of light therapy on serotonin transporter binding (5‐ HTT BP ND ), an index of 5‐ HTT levels, in the anterior cingulate and prefrontal cortices ( ACC and PFC ) during winter in seasonal affective disorder ( SAD ). 5‐ HTT BP ND fluctuates seasonally to a greater extent in SAD relative to health. We hypothesized that in SAD , 5‐ HTT BP ND would be reduced in the ACC and PFC following light therapy. Methods Eleven SAD participants underwent [ 11 C] DASB positron emission tomography ( PET ) scans to measure 5‐ HTT BP ND before and after 2 weeks of daily morning light therapy. Results The primary finding was a main effect of treatment on 5‐ HTT BP ND in the ACC and PFC (repeated‐measures manova , F (2,9) = 6.82, P = 0.016). This effect was significant in the ACC ( F (1,10) = 15.11 and P = 0.003, magnitude of decrease, 11.94%) and PFC ( F (1,10) = 8.33, P = 0.016, magnitude of decrease, 9.13%). 5‐ HTT BP ND also decreased in other regions assayed following light therapy (repeated‐measures manova , F (4,7) = 8.54, P = 0.028) including the hippocampus, ventral striatum, dorsal putamen, thalamus and midbrain ( F (1,10) = 8.02–36.94, P < 0.0001–0.018; magnitude −8.83% to −16.74%). Conclusions These results demonstrate that light therapy reaches an important therapeutic target in the treatment of SAD and provide a basis for improvement of this treatment via application of [ 11 C] DASB PET .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".