Effectiveness of platelet‐rich plasma treatment in patients with chronic corneal erosions, associated with Herpetic keratitis
Bibliographic record
Abstract
Purpose 3 courses of platelet‐rich plasma (PRP) instillations were investigated for their effect on corneal epithelialization, in cases, associated with Herpetic keratitis Methods The study involved 21 patients with chronical corneal erosions of Herpetic keratitis origin. Etiology was confirmed by immunosorbent immunoglobulins M, G assay for Herpes Simplex Virus 1,2, Cytomegalovirus and Virus Epstein ‐ Barrie. All patients had previous unsuccessful courses of reparative therapy. First step of treatment consist of local and systemic antiviral therapy (Gancyclovir eye gel 0.15% and Valcyclovir). After the antiviral therapy, common volume 15 ml. of blood, taken from patients cubital vein, was mixed with anticoagulant (Sodium citrate with Dextrosa), and undergone a double centrifugation for 4 min. at 3,500 rpm. Patients were receiving: PRP instillations 6 times a day in combination with subconjunctival injection ones a week, Sulfated glicosaminoglicans 0.01% 4 times a day, Dexpanthenol 5% 4 times a day. Course of treatment was 3 weeks, procedure of obtaining PRP was performed 1 time per week. Dynamic of the treatment was assessed by Efron scale (cornea fluorescein coloring at 5 sectors in points). The patient's condition before therapy was used as a control. Results The average index of the corneal lesion before treatment was 9.7 points. After the 1st and 2nd procedure average lesion index was 8.2 and 5.9 points respectively. After 3 weeks, complete epithelization was observed in 12 patients. In 6 patients a gradual disappearance of the epithelial defects was shown after 5–6 courses. 3 patients did not respond to the treatment. Conclusions PRP treatment showed positive dynamic in cases of previously unsuccessfully treated chronical corneal erosion.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".