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Record W2519464905 · doi:10.1016/j.bbi.2016.09.004

Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice

2016· article· en· W2519464905 on OpenAlexaff
Éva Borbély, Zsófia Hajna, Liza Nabi, Bálint Scheich, Valéria Tékus, Kristóf László, Tamás Ollmann, Viktória Kormos, Balázs Gaszner, Zoltán Karádi, László Lénárd, Christopher J. Paige, John P. Quinn, Janós Szolcsányi, Erika Pintér, Julie Keeble, Alexandra Berger, Zsuzsanna Helyes

Bibliographic record

VenueBrain Behavior and Immunity · 2016
Typearticle
Languageen
FieldNeuroscience
TopicNeuropeptides and Animal Physiology
Canadian institutionsPrincess Margaret Cancer CentreUniversity Health Network
FundersEuropean Social FundPécsi TudományegyetemEuropean Commission
KeywordsTail suspension testSubstance POpen fieldBehavioural despair testElevated plus mazeAnxiolyticNK1 receptor antagonistInternal medicineEndocrinologyTachykinin receptor 1ReceptorAntagonistPharmacologyReceptor antagonistChemistryPsychologyNeuropeptideMedicineAnxietyHippocampusPsychiatryAntidepressant

Abstract

fetched live from OpenAlex

mice. Our results provide the first evidence for an anxiolytic and anti-depressant-like actions of HK-1 through a presently unknown target-mediated mechanism. Identification of its receptor and/or signaling pathways might open new perspectives for anxiolytic and anti-depressant therapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.783
Threshold uncertainty score0.365

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.293
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2016
Admission routes1
Has abstractyes

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