Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
目的 探讨血浆白介素17、白介素27（Interleukin 17、27，IL-17、IL-27）细胞因子在多发性硬化（Multiple sclerosis,MS）中的作用及可能机制，并分析多发性硬化患者认知功能障碍状况。\n方法 收集兰州大学第二医院神经内科2010 年3 月至2015 年10 月急性期缓解-复发型多发性硬化患者和体检中心健康对照组各45例的血浆,采用酶联免疫法检测血浆IL-17、IL-27的水平变化；并结合扩展残疾状况评分量表(Expanded disability status scale，EDSS )评分、头颅核磁共振（M R I）增强病灶数目、简易精神状态量表（Mini-Mental State Examination，MMSE）和蒙特利尔认知功能量表(Montreal cognitive assessment scale，MoCA)评分统计；利用IBM SPSS 23 软件对组间数据采用独立样本t 检验、组内数据采用配对样本的t 检验；病例组治疗前变量采用Pearson相关性分析。\n结果 ⑴病例组治疗前与健康对照组比较血浆IL-17水平升高而IL-27降低（P＜0.05）；治疗4周后与治疗前比较IL-17降低、相反IL-27升高（P ＜0.05）。\n⑵病例组治疗前与治疗4周后比较EDSS 评分降低（P ＜ 0.05）、而头颅M R I增强病灶数目比较无统计学意义（P ＞ 0.05）。\n⑶病例组MMSE、MoCA测评总分与健康对照组比较降低（P ＜ 0.05）。\n⑷IL-17与IL-27成负相关性（r=-0.375）；IL-17与EDSS评分、头颅MRI增强病灶数目均成正相关(r= 0.360，r= 0.334)；IL-27与EDSS 评分、头颅M R I增强病灶数、MMSE评分、MoCA评分分别成负相关(r= -0.319，r= -0.429，r=-0.356；r=-0.302)；MMSE评分与EDSS 评分、头颅MRI增强数目、病程分别成正相关（r=0.350、r=0.357、r=0.514 ）；MoCA评分与EDSS 评分、头颅MRI增强数目和病程分别成正相关（r=0.362、 r=0.321、r=0.538）。\n结论 推测在多发性硬化中IL-17起到促炎作用而IL-27具有抑制炎症反应的作用。IL-17、IL-27作为重要的细胞因子参与多发性硬化的病理生理过程。可能通过调节IL-17、IL-27可抑制MS患者的炎症反应、改善症状。而且发现多发性硬化患者早期存在认知功能障碍。因此,IL-17、IL-27对多发性硬化的发病机制、诊断、治疗提供了新的思路和方向。
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it