Prenylated Coumarins from Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Coumarins are typical secondary metabolites accumulated in the families Apiaceae (Umbelliferae) [ 1 ] and Rutaceae [ 2 ]. The widespread incorporation of prenyl units resulted in the structural diversity of coumarins in both families [ 2 ]. Particularly, the genera Heracleum and Peucedanum from Apiaceae can be characterized by the dominance of furanocoumarins [ 3 ] and pyranocoumarins [ 4 ], respectively. Coumarins possessed diverse pharmacological properties, in which the cytotoxic effects were most extensively examined [ 5 ]. As part of a BioBioPha ( http://www.chemlib.cn/ ) objective to assemble a large-scale natural product library valuable in the discovery of new drug leads from nature [ 6 , 7 ], four new prenylated coumarins Fig. 1 , namely 6″- O - β - d -apiofuranosylapterin ( 1 ), 4′- O -isobutyroylpeguangxienin ( 2 ), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin ( 3 ), and 6-hydroxycoumurrayin ( 4 ), were isolated from the ethanol extract of Heracleum stenopterum , Peucedanum praeruptorum , Clausena lansium , and Murraya paniculata , respectively. This paper described the structure elucidation of new coumarins and their cytotoxicity evaluation against five human cancer cell lines.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it