MétaCan
Menu
Back to cohort
Record W2525167936

Soy isoflavones and breast cancer

2002· article· es· W2525167936 on OpenAlexvenueno aff
Kevin McLaughlin

Bibliographic record

VenueJournal of orthomolecular medicine · 2002
Typearticle
Languagees
FieldMedicine
TopicPhytoestrogen effects and research
Canadian institutionsnot available
Fundersnot available
KeywordsIsoflavonesMedicineEstrogenBreast cancerPhysiologyCancerOsteoporosisGenisteinMenopauseInternal medicineEndocrinologyPopulationPhytoestrogensEnvironmental health
DOInot available

Abstract

fetched live from OpenAlex

Introduction It has been recognized for several decades that the use of legumes in traditional eastern diets has played a significant role in the incidence and mortality of certain disease states. Soy beans and products containing soy possess unique phytochemicals known as isoflavones which are thought to exert many biological effects in the human body. Scientists have proposed that these unique isoflavones have hormonal influences which can interact with many different cell types producing varied physiological responses. Epidemiological data, human cell line studies, randomized trails and review articles have consistently shown that certain population groups (Asians, vegetarians) who regularly consume a soy-based diet are afforded protection from breast cancer, endometrial cancer, prostate cancer, heart disease, osteoporosis, and symptoms of hormonal deficiency. Typically, Japanese women have higher levels of circulating and urinary isoflavones compared to Western women with concomitant lower rates of hormone-dependent cancers. Japanese women also have lower rates of osteoporosis, heart disease and menopausal complaints. Researchers have postulated that soy isoflavones may act as weak estrogen antagonists by influencing estrogenic metabolism and menstrual cycle length in premenopausal women but may concurrently act as weak estrogen agonists in postmenopausal women. Breast cancer has been associated with higher circulating levels of estradiol and prolactin with lower levels of progesterone. The proposition, therefore, has been made that soy isoflavones may modulate breast cancer risk in menopausal women but may also afford protection to the bones, cardiovascular and

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.481
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.317
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2002
Admission routes1
Has abstractyes

Explore more

Same venueJournal of orthomolecular medicineSame topicPhytoestrogen effects and researchFrench-language works237,207