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Novel genetic loci underlying human intracranial volume identified through genome-wide association
Hieab H.H. Adams, Derrek P. Hibar, Vincent Chouraki, Jason L. Stein, Paul Nyquist, Miguel E. Rentería, Stella Trompet, Alejandro Arias Vásquez, Sudha Seshadri, Sylvane Desrivières, Ashley Beecham, Neda Jahanshad, Katharina Wittfeld, Sven J. van der Lee, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S. Aribisala, Nicola J. Armstrong, Lavinia Athanasiu, Tomas Axelsson, Alexa Beiser, Manon Bernard, Laura M. E. Blanken, Susan H. Blanton, Marc M. Bohlken, Marco P. Boks, Janita Bralten, Adam M. Brickman, Owen Carmichael, M. Mallar Chakravarty, Ganesh Chauhan, Qiang Chen, Christopher R. K. Ching, Gabriel Cuéllar-Partida, Anouk den Braber, Nhat Trung Doan, Stefan Ehrlich, Irina Filippi, Tian Ge, Sudheer Giddaluru, Aaron L. Goldman, Rebecca F. Gottesman, Corina U. Greven, O. Grimm, Michael Griswold, Tulio Guadalupe, Johanna Haß, Unn K. Haukvik, Saima Hilal, Edith Hofer, David Hoehn, Avram J. 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Bibliographic record
VenueNature Neuroscience · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsMontreal Neurological Institute and HospitalSickKids FoundationUniversity of TorontoUniversity of CalgaryTrinity CollegeDouglas Mental Health University InstituteMcGill UniversityHospital for Sick Children
FundersScottish Mental Health Research NetworkU.S. National Library of MedicineNational Institute of Biomedical Imaging and BioengineeringNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Cancer InstituteNational Human Genome Research InstituteNational Institute of Mental HealthNational Institutes of Natural SciencesStichting voor de Technische WetenschappenJapan Society for the Promotion of ScienceNational Health and Medical Research CouncilAustralian Research CouncilBiotechnology and Biological Sciences Research CouncilMedical Research CouncilAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalHeart And Stroke Foundation Of QuebecUniversity of California, San DiegoGenentechDirectorate for Biological SciencesNational Institutes of HealthMax Planck Instituut voor PsycholinguïstiekNational Institute on AgingUniversität GreifswaldEpilepsy SocietyIXICOErasmus Medisch CentrumUniversity College London Hospitals NHS Foundation TrustMutuelle Générale de l'Education NationaleServierUppsala UniversitetUniversity of New South WalesRadboud Universitair Medisch CentrumNational Center for Research ResourcesGenome Institute of SingaporeUniversitair Medisch Centrum GroningenBiomedical Research CouncilUniversitetet i BergenMax-Planck-GesellschaftKuopion Yliopistollinen SairaalaNederlandse Organisatie voor Wetenschappelijk OnderzoekFondation pour la Recherche MédicaleMedizinische Universität GrazNational Institute for Health and Care ResearchAustrian Science FundVrije Universiteit AmsterdamZonMwUniversity of MelbourneCentre for Cognitive Ageing and Cognitive EpidemiologyNational Medical Research CouncilNorges ForskningsrådStockholms Läns LandstingNational Heart, Lung, and Blood InstituteUniversiteit LeidenInstitut National de la Santé et de la Recherche MédicaleCentre hospitalier régional universitaire de LilleNorthern California Institute for Research and EducationAgency for Science, Technology and ResearchCanadian Institutes of Health ResearchKnut och Alice Wallenbergs StiftelseEuropean CommissionParkinson's UKHersenstichtingU.S. Department of DefenseCommonwealth Scientific and Industrial Research OrganisationBroad InstituteAustralian GovernmentRadboud UniversiteitRussian Foundation for Basic ResearchRoyal College of Surgeons in IrelandEpilepsy Research UKScottish Funding CouncilUniversity College LondonMassachusetts General HospitalHarvard UniversityTranslational Genomics Research InstituteEpilepsy IrelandTexas Biomedical Research InstituteSvenska Forskningsrådet FormasKarl-Franzens-Universität GrazMrs Gladys Row Fogo Charitable TrustCentre d'Imagerie BioMédicaleEisaiSanofiLeids Universitair Medisch CentrumFoundation for the National Institutes of HealthNational Alliance for Research on Schizophrenia and DepressionHjartaverndBergens ForskningsstiftelseJapan Agency for Medical Research and DevelopmentNovartis Pharmaceuticals CorporationFundación Marqués de ValdecillaDevelopment of Innovative Strategies for a Transdisciplinary approach to ALZheimer's diseaseWellcome TrustAgence Nationale de la RechercheJohns Hopkins UniversityPfizerCalifornia NanoSystems InstituteBiogenBioClinicaScience Foundation IrelandFondation LeducqNational Science FoundationVetenskapsrådetUniversiteit UtrechtUniversity of MinnesotaScience for Life LaboratoryFondation de FranceUniversity of TorontoInstituto de Salud Carlos IIISynarcLundbeckfondenAccareAge UKEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentBrain Research Imaging Centre, University of EdinburghUniversity of Southern CaliforniaGlaxoSmithKlineHeart and Stroke Foundation of CanadaItä-Suomen YliopistoKoninklijke Nederlandse Akademie van WetenschappenEli Lilly and CompanyAutism SpeaksBristol-Myers SquibbMeso Scale DiagnosticsUniversité de LilleKarolinska InstitutetU.S. Department of EnergyNational University Health SystemAlzheimer's AssociationNational Center for Advancing Translational SciencesBundesministerium für Bildung und ForschungMinistry of Education, Culture, Sports, Science and TechnologyMedpace
KeywordsNeuroscienceGenome-wide association studyBiologyNeuroscientistBrain sizeAssociation (psychology)Systems neuroscienceGenomeHuman genomeEvolutionary biologyGeneticsComputational biologyPsychologyGeneSingle-nucleotide polymorphismMedicineGenotypeCentral nervous systemMagnetic resonance imaging
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.859
Threshold uncertainty score0.580
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.022
GPT teacher head0.295
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations261
Published2016
Admission routes2
Has abstractno