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Record W2528508895 · doi:10.1038/gim.2016.147

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk

2016· article· en· W2528508895 on OpenAlexaff
Taru Muranen, Dario Greco, Carl Blomqvist, Kristiina Aittomäki, Sofia Khan, Frans B.L. Hogervorst, Senno Verhoef, Paul D.P. Pharoah, Alison M. Dunning, Mitul Shah, Robert Luben, Stig E. Bojesen, Børge G. Nordestgaard, Minouk J. Schoemaker, Anthony J. Swerdlow, Montserrat García‐Closas, Jonine D. Figueroa, Thilo Dörk, Natalia Bogdanova, Per Hall, Jingmei Li, Э. К. Хуснутдинова, Marina Bermisheva, Vessela Kristensen, Anne‐Lise Børresen‐Dale, Julian Peto, Isabel dos‐Santos‐Silva, Fergus J. Couch, Janet E. Olson, Peter Hillemans, Tjoung‐Won Park‐Simon, Hiltrud Brauch, Ute Hamann, Barbara Burwinkel, Frederik Marmé, Alfons Meindl, Rita K. Schmutzler, Angela Cox, Simon S. Cross, Elinor J. Sawyer, Ian Tomlinson, Diether Lambrechts, Matthieu Moisse, Annika Lindblom, Sara Margolin, Antoinette Hollestelle, John W.M. Martens, Peter A. Fasching, Matthias W. Beckmann, Irene L. Andrulis, Julia A. Knight, Hoda Anton‐Culver, Argyrios Ziogas, Graham G. Giles, Roger L. Milne, Hermann Brenner, Volker Arndt, Arto Mannermaa, Veli‐Matti Kosma, Jenny Chang‐Claude, Anja Rudolph, Peter Devilee, Caroline Seynaeve, John L. Hopper, Melissa C. Southey, Esther M. John, Alice S. Whittemore, Manjeet K. Bolla, Qin Wang, Kyriaki Michailidou, Joe Dennis, Douglas F. Easton, Marjanka K. Schmidt, Heli Nevanlinna

Bibliographic record

VenueGenetics in Medicine · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsLunenfeld-Tanenbaum Research InstitutePublic Health OntarioUniversity of TorontoMount Sinai Hospital
FundersMedical Research and Materiel CommandNational Cancer InstituteCancer Council VictoriaCancer Council South AustraliaMedical Research CouncilU.S. ArmyFonds Wetenschappelijk OnderzoekCancer Council NSWNational Health and Medical Research CouncilNorges ForskningsrådBreast Cancer Research FoundationUniversity of CambridgeWellcome TrustCancer Research UKLon V. Smith FoundationNational Institute for Health and Care ResearchCancer Council TasmaniaDavid F. and Margaret T. Grohne Family FoundationNational Institutes of HealthNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchNational Breast Cancer FoundationFrancis Crick InstituteNederlandse Organisatie voor Wetenschappelijk OnderzoekEuropean Commission
KeywordsCHEK2Breast cancerMedicineOncologyGeneticsBiologyInternal medicineCancerGeneMutationGermline mutation

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.547
Threshold uncertainty score0.566

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.286
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations87
Published2016
Admission routes1
Has abstractno

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