Hydrogen Sulfide Regulates the [Ca<sup>2+</sup>]<sub>i</sub> Level in the Primary Medullary Neurons
Bibliographic record
Abstract
In the present study, we attempted to elucidate mechanisms for the regulation of intracellular calcium levels by H 2 S in primary rat medullary neurons. Our results showed that NaHS significantly increased the level of in rat medullary neurons in a concentration‐dependent manner. L‐Cysteine and SAM significantly raised the level of in the medullary neurons while HA and/or AOAA produced a reversal effect. In addition, L‐cysteine and SAM significantly increased but HA and/or AOAA decreased the production of H 2 S in the cultured neurons. The elevation induced by H 2 S was significantly diminished by EGTA‐Ca 2+ ‐free solutions, and this elevation was also reduced by nifedipine or nimodipine and mibefradil, suggesting the role of L‐type and/or T‐type Ca 2+ channels. Moreover, the effect of H 2 S on level in neurons was significantly attenuated by BAPTA‐AM and thapsigargin, suggesting the source of Ca 2+ . Therefore, we concluded that both exogenous and endogenous H 2 S elevates level in primarily cultured rat medullary neurons via both increasing calcium influx and mobilizing intracellular Ca 2+ stores from ER.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".