EFFECTS OF PROTEIN-ENERGY MALNUTRITION ON SPONTANEOUS MOTOR RECOVERY AFTER STROKE
Bibliographic record
Abstract
The development of comorbidity factors such as malnutrition may compromise functional recovery following stroke. The objectives of this study were to elucidate the effects of post-stroke protein-energy malnutrition (PEM) on infarct size, spontaneous motor recovery, and the acute phase response in the chronic period. \nAdult, male (12 week old) Sprague-Dawley rats were trained for at least 14 days in the Montoya staircase. Food intake was monitored daily and body weight was recorded weekly. Just prior to inducing stroke, rats were tested in the cylinder and Montoya staircase to determine baseline values for forelimb use during spontaneous exploration and skilled reaching, respectively. These animals were then subjected to photothrombotic stroke targeted to the motor cortex or sham surgery. Animals were tested in the cylinder on day 4 after surgery, before assignment to either control diet (12.5 % protein) or PEM (0.5 % protein) (n= 6-9/experimental group), and again on days 16 and 29. The staircase was abandoned for post-stroke testing because training criteria were not met. On Day 30, blood, brain, and liver were collected for biochemical or histological analysis. \nFeeding the low protein diet resulted in PEM as measured by decreased body weight p<0.001), food intake (p=0.016), and serum albumin (p<0.001) and increased liver lipid (p<0.001) and serum A2M (p=0.001). Both stroke (p=0.016) and PEM (p=0.001) elicited increases in the positive acute phase protein, A2M.\nThe effect of PEM on post-stroke cylinder performance varied by specific endpoint. PEM exacerbated forelimb asymmetry during vertical exploration on Days 16 and 29 when scored by method 1 (p≤ 0.024), and this was not due to a change in infarct size (p=0.775). Scoring exploration by method 2 and initiation of exploration by first touch demonstrated similar patterns for preferred limb use after stroke, although these endpoints were not significantly affected by PEM (p≥0.301). The score for takeoff to initiate exploration was also impaired by stroke (p<0.001), but PEM had no influence (p=0.463). Termination of exploration (landing) was not influenced by stroke (p=0.332), and there was no independent effect of PEM (p=0.959).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".