Efficacy of Short-term Teriparatide for Hip Osteonecrosis
Bibliographic record
Abstract
To the Editor: Osteonecrosis of the femoral head is the result of the lack or decrease of blood supply to the bone leading to bone and cartilage cellular death, fracture, and finally collapse of articular surface1. The pathogenesis is still unclear, but it seems that it is the result of a variety of traumatic and atraumatic factors such as genetic predisposition and metabolic factors. Risk factors are high-dosage glucocorticoids, alcohol abuse, venous stasis, adipocyte hypertrophy, alteration of circulating lipids, and other diseases that facilitate intravascular coagulation and thrombus formation2. Nonsurgical treatment is limited and consists of physical therapy and rehabilitation, protected weight-bearing, hyperbaric therapy, and the use of nonsteroidal antiinflammatory drugs (NSAID), bisphosphonates, nifedipine, and lipid-lowering agents3. Unfortunately, these treatments have shown not a real efficacy, but only partial results on pain or delaying fracture and articular collapse4. Teriparatide (TPT), a recombinant synthetic version of the human parathyroid hormone (PTH), is a bone anabolic … Address correspondence to Dr. F. Galluccio, SOD Reumatologia, Viale Pieraccini 18, Villa Monnatessa, 50139 Florence, Italy. E-mail: felicegalluccio{at}gmail.com
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.010 | 0.007 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".