Dengue virus replication by platelets
Bibliographic record
Abstract
Dengue virus ( DENV ) causes >100 million febrile infections annually. In ~2 million of these individuals, the disease may progress into life‐threatening haemorrhagic fever or shock syndrome. Approximately 200 million high‐titre infections remain asymptomatic and are a documented risk for transfusion transmission. Interestingly, both mild and severe DENV infections result in thrombocytopenia. Well‐established DENV receptors studies have suggested that similar receptors on platelets may facilitate comparable binding. To help explain DENV ‐mediated platelet pathology, indirect evidence for a DENV ‐platelet interaction with possible cell entry and direct binding has been reported. Increasing evidence has established that platelets contain the necessary translational machinery to generate protein from RNA . Since DENV has an RNA genome, we hypothesized that platelets are permissive to DENV replication. Using highly purified DENV and platelets, a specific dendritic cell‐specific intercellular adhesin molecule‐3‐grabbing non‐integrin/heparan proteoglycan coreceptor binding system was identified. Demonstrating de novo virus protein and genome generation and production of infectious progeny by viable platelets now adds to the understanding of DENV ‐associated thrombocytopenia. Of importance to global blood systems, donor‐derived platelet concentrates ( PC s) and red‐blood‐cells units ( RBC s) also replicated viral RNA . In each case, DENV underwent spontaneous logarithmic decay which was offset by the production of new virus progeny. While DENV persisted through the duration of PC and RBC storage, these data suggest the possibility that older units may be less infectious. We speculate that platelets may be active contributors to virus infection, and in the case of viruses with an RNA genome, platelets may initially serve as replication centers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".