PO-31 EFFECT OF POOR GLYCEMIC CONTROL ON ARTERIAL STIFFNESS IN PREGNANCY
Bibliographic record
Abstract
Objectives: Poor glycemic control during pregnancy is associated with increased adverse perinatal outcomes. Our objective was to characterize the association between glycemic control and arterial stiffness in pregnancy. Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited from obstetrical clinics in Montreal, Canada. Arterial stiffness was measured in women with gestational diabetes (GDM) or pre-existing diabetes mellitus (DM) using applanation tonometry (SphygmoCor; AtCor) starting at 24 weeks’ gestation (the period at which GDM screening is performed for all women according to standard clinical practice) and every 4 weeks thereafter until delivery. Arterial stiffness indices were compared between women with poor glycemic control and women with adequate glycemic control. Poor glycemic control was defined as average HbA1C > 7%, average fasting glucose > 5.3 mmol/L, average 1h post-prandial glucose > 7.8 mmol/L, insulin dosage > 30 units, large for gestational age fetus, or maximal vertical pocket > 8 cm. Results: Of the 35 women who delivered in this ongoing study and had GDM (n=18) or DM (n=17), 12 had poor glycemic control throughout their pregnancy. Longitudinal analyses adjusted for maternal age, body mass index, and medical history, showed women with poor glycemic control had significantly increased carotid-radial pulse wave velocity (PWV) at each timepoint: 26–30 weeks: 8.4 vs. 8.0 m/s, p = 0.04; 30–34 weeks: 8.4 vs. 8.1 m/s, p <0.01; 34–38 weeks: 8.5 vs. 8.1 m/s, p = 0.02. No differences were found in carotid-femoral PWV, augmentation index adjusted for a heart rate of 75 beats per minute, or start time of wave reflection between these 2 cohorts. Conclusion: Women who had poor glycemic control throughout pregnancy showed increased peripheral arterial stiffness from the late 2nd trimester until delivery. Our ongoing study will provide more definite conclusions with increased population size.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".