Gastroesophageal Reflux Disease in HIV-Infected Adults: Prevalence and Risk Factors of Moderate-Severe or Frequent Symptoms
Bibliographic record
Abstract
Background. Gastroesophageal reflux disease (GERD) is common in the general population but its burden is unknown in HIV-infected adults. The aim of the study is to determine the prevalence of GERD and the clinical characteristics and risk factors associated with moderate-severe or frequent GERD symptoms among HIV-infected adults. Methods. We conducted a cross-sectional study of 120 HIV-infected adults from two HIV clinics in Canada. The patients completed a validated GERD questionnaire during their clinic visits. GERD was defined as the presence of heartburn, acid regurgitation, or both. We considered two categories: symptoms occurring once a week or more as frequent, and those that cannot be ignored and affect the patient's life as moderate-severe. A multivariate logistic regression analysis was used to assess risk factors associated with frequent or moderate-severe GERD symptoms. Results. Eighty five HIV-infected adults were included in the analysis. Mean age was 44 years and median body mass index (BMI) was 25. Of the 68(81%) adults with GERD, 36 (52.9%) were classified as frequent and 42 (61.8%) moderate-severe. Sixty-five(95.6%) patients who had GERD symptoms were taking medication to treat it. The majority of patients (92.3%) were on histamine 2 receptor antagonists. Twenty-two patients had metabolic syndrome, of whom 19 (86.4%) had GERD symptoms. From the multivariate analysis, taking medications for GERD was the only variable associated with moderate to severe or frequent GERD symptoms (OR = 14.7; 95% CI: 3.4- 62.9, P = 0.04). BMI and metabolic syndrome were not associated with GERD or its severity and frequency. Conclusion. GERD is prevalent among HIV-infected adults, and over half of patients present with symptoms described as frequent and/or moderate-severe in intensity. Screening and management of GERD are important considerations as part of routine HIV care. Disclosures. All authors: No reported disclosures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".