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Record W2560183138

Challenges of T3 and T4 Translational Research.

2016· article· en· W2560183138 on OpenAlexvenueno aff
Jr. Charles J. Vukotich

Bibliographic record

VenueJournal of research practice · 2016
Typearticle
Languageen
FieldMedicine
TopicHealth and Medical Research Impacts
Canadian institutionsnot available
Fundersnot available
KeywordsTranslational researchTranslational scienceMedical researchTranslational medicineEngineering ethicsTranslational research informaticsPolitical sciencePublic relationsMedicineHealth careSociologySocial scienceEngineeringHealth informatics
DOInot available

Abstract

fetched live from OpenAlex

Translational research is a new and important way of thinking about research. It is a major priority of the National Institutes of Health (NIH) in the United States. NIH has created the Clinical and Translational Science Awards to promote this priority. NIH has defined T1 and T2 phases of translational research in the medical field, in order to bring the benefits of scientific results into communities. Current discussions focus on clarifying the subsequent phases of translational research necessary to achieve the intended social impact of research. This article suggests that T3 translational research could aim at getting research out of the highly controlled environment of the academic health center and into the real world. Likewise, it suggests T4 translational research could aim at policy development through policy analysis and evaluation, cost-benefit analysis, and surveillance studies. Translational research has challenges beyond definitions. Translational research is incomplete at any level unless appropriate steps are taken to communicate the results to relevant stakeholders. It appears that communication is currently suboptimal at all levels of translation. Translational research also faced challenges in research funding and training of researchers. Translational thinking should be a key part of research policy and research practice at all levels.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.482
metaresearch head score (Gemma)0.420
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.518
Threshold uncertainty score0.639

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.4820.420
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0040.005
Bibliometrics0.0050.005
Science and technology studies0.0110.074
Scholarly communication0.0330.037
Open science0.0110.028
Research integrity0.0280.038
Insufficient payload (model declined to judge)0.0120.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.693
GPT teacher head0.658
Teacher spread0.035 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designTheoretical or conceptual
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2016
Admission routes1
Has abstractyes

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