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Record W2563079942 · doi:10.1017/cjn.2016.415

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

2016· article· en· W2563079942 on OpenAlex
Sali M.K. Farhan, Robert Bartha, Sandra E. Black, Dale Corbett, Elizabeth Finger, Morris Freedman, Barry Greenberg, David A. Grimes, Robert A. Hegele, Chris Hudson, Peter Kleinstiver, Anthony E. Lang, Mario Masellis, William E. McIlroy, Paula McLaughlin, Manuel Montero‐Odasso, David G. Munoz, Douglas P. Munoz, Stephen C. Strother, Sean Symons, Maria Carmela Tartaglia, Lorne Zinman

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
venuePublished in a venue whose home country is Canada.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2016
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsQueen's UniversityToronto Western HospitalHealth Sciences CentreUniversity Health NetworkOttawa HospitalUniversity of WaterlooToronto Dementia Research AllianceWestern UniversityUniversity of TorontoBaycrest HospitalUniversity of OttawaSt. Michael's HospitalSunnybrook Health Science Centre
FundersFaculty of Health Sciences, Queen's UniversityCentre for Addiction and Mental Health FoundationCanadian Institutes of Health ResearchLondon Health Sciences FoundationStrongQueen's UniversityMcMaster UniversityTemerty Family FoundationUniversity of OttawaHeart and Stroke Foundation of CanadaOntario Brain InstituteGovernment of Ontario
KeywordsFrontotemporal dementiaDiseaseAmyotrophic lateral sclerosisNeuroimagingDementiaCognitionMedicineNeurosciencePsychologyPhysical medicine and rehabilitationPathology

Abstract

fetched live from OpenAlex

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.007
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesScience and technology studies
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.340
Threshold uncertainty score0.995

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0100.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0060.017
Scholarly communication0.0010.001
Open science0.0020.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.102
GPT teacher head0.355
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it