Abstract 1629: Prednisone versus dexamethasone acute toxicity and cumulative doses variations in childhood acute lymphoblastic leukemia
Bibliographic record
Abstract
Abstract INTRODUCTION Glucocorticoids (GC) are the main components of childhood acute lymphoblastic leukemia (ALL) treatment; in the past decades, there were numerous attempts at finding whether prednisone or dexamethasone is the best drug. EXPERIMENTAL PROCEDURE A retrospective study of patients (n = 119) treated according to Dana-Farber Cancer Institute (DFCI)-ALL treatment protocols 91-01 and 95-01 was done. Medical charts were reviewed and type and doses of glucocorticoids (GC) received were recorded. Bone and psychiatric symptoms, as well as all anthropomorphic data were also recorded. For each patient, a total theoretical dose was calculated according to the initial risk of relapse stratification, treatment protocol indications and assigned arms. Cumulative GC doses actually received were compared to theoretical doses in the form of a dose deviation in% ((theoretical dose - actual dose) / theoretical dose * 100). SUMMARY OF DATA Results indicate that despite an adequate correlation between planned and administered GC doses for most patients, patients treated with dexamethasone were found to have significantly more GC dose deviations than those treated with prednisone (p < 0.001). Findings also indicate that bone toxicity (p = 0.02), but not psychiatric toxicity, is associated with GC dose deviations. CONCLUSIONS Despite representing the current standard in clinical studies, using only different treatment arms or different treatment protocols may lead to significant interpretation caveats if doses actually received are not controlled for. This is of importance especially for drugs likely to induce very severe side-effects requiring dose modification, as it is the case for GC and acute bone toxicity. Citation Format: Sophie Marcoux, Aurélie Chapdelaine, Philippe Robaey, Daniel Sinnett, Maja Krajinovic, Caroline Laverdière. Prednisone versus dexamethasone acute toxicity and cumulative doses variations in childhood acute lymphoblastic leukemia. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1629. doi:10.1158/1538-7445.AM2015-1629
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".