Frontotemporal Dementia (FTD) with Late-Onset Obsessive-Compulsive Symptoms (OCs): An Individual-Patient Data Meta-Analysis (P6.246)
Bibliographic record
Abstract
Objective: To meta-analytically identify OCD and OCs in FTD to evaluate their onset and significance. Background: 65[percnt] of patients with FTD behavioral variant (FTDbv) have perseverative, stereotyped or compulsive/ritualistic behaviors. The relationship between Obsessive-Compulsive Disorder (OCD), OCs and FTD has not been well studied. Method: Individual-patient data meta-analysis was conducted based on case-reports available on PubMed (N=29) and EMBASE (N=84). Inclusion criteria consisted of FTD/Frontotemporal lobar degeneration cases with OCs or OCD. Clinical and demographic characteristics were set a priori and examined for frequency and distribution. Results: There were 23 individuals included with the diagnoses: FTDbv (n=15), Semantic Dementia (n=4), Nonfluent Primary Progressive Aphasia with Progresive Supranuclear Palsy (PSP) (n=1), Cortico-Basal Syndrome with PSP (n=1); and FTD with motor neuron disease (n=2) who had OCs or OCD. There were no uniform diagnostic criteria for OCD/OCs used across case-reports. Because of this, we selected OCD/OCs cases using the reported diagnosis of OCD or OCs. Average age was 55.5 years (SD: 12.9; n: 23), and 56.5[percnt] were male. Average MMSE was 25.9 (SD: 3.3; n=12), MoCA mean: 21 (SD: 4.6, n=3), while others did not report measure of cognition. 56.5[percnt] of cases reported OCD, and the remaining OCs. 78.3[percnt] of cases developed OCD/OCs 0 to 27 years before the clinical diagnosis of FTD (average 5.4 years, SD: 7.2); 17.4[percnt] occurred concurrently, and the remaining developed OCD/OCs up to 7 years after FTD diagnosis. 65[percnt] of cases reported additional neuropsychiatric symptoms, and anxiety, depression and psychosis (13[percnt] each) were the most prevalent. Conclusion: OCs most frequently occur prior to the clinical diagnosis of FTD (in 78.3[percnt] of cases, 0 to 27 years before) and also co-occur with other psychiatric conditions like anxiety, depression and psychosis. Late-onset OCs can precede frank FTD, and thus merit further attention as an early marker of FTD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.015 | 0.022 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.011 | 0.036 |
| Bibliometrics | 0.004 | 0.005 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".