P705 Peripheral arterial disease is associated with an increased risk of elderly-onset inflammatory bowel disease
Bibliographic record
Abstract
Background: The less aggressive natural history and lower genetic predisposition in elderly-onset inflammatory bowel disease (EO-IBD) suggest a unique disease pathophysiology in the elderly. Given the theoretical role of intestinal microvascular ischemia in IBD pathogenesis, we aimed to assess if peripheral arterial disease increases the risk of EO-IBD. Methods: We conducted a case-control study using a national medical claims and pharmacy database from Source Healthcare Analytics LLC, containing data from January 2008 to December 2012. Incident cases of EO-IBD were defined as: 1) ≥60 years old, 2) ≥3 ICD-9 codes for either Crohn's Disease (CD) or Ulcerative Colitis (UC) in 2012, and 3) no IBD-related prescriptions or IBD ICD-9 codes for patients between 2008 and 2011. EO-IBD patients with a history of ischemic colitis were excluded. Controls had no IBD-related medications, IBD ICD-9 codes, IBD-associated autoimmune disease or ischemic colitis. Controls were matched to cases by age group, gender, race and geographic location. Patients were determined to have peripheral arterial disease (PAD) if they had one or more of the following ICD-9 codes on or before the first IBD code: 440.2–440.4, 443.89, 443.9. Conditional logistic regression was performed to assess the association of PAD with EO-IBD. All models were adjusted for age, vascular risk factors and diseases (diabetes, hypertension, hyperlipidemia, obesity, coronary artery disease, cerebrovascular disease) and medications previously associated with new-onset IBD (statins, antibiotics and hormone therapy). Results: In the analysis, 3846 EO-IBD cases (CD =1479, UC =2097, IBD-U =270) and 19,222 controls were included. Baseline characteristics and the distribution of vascular comorbidities between cases and controls are shown in Table 1. Table 1. Baseline characteristics and vascular comorbidities Categorical values are reported as n (%). After controlling for vascular and medication confounders, PAD was significantly associated with an increased risk of EO-IBD (OR 1.52, 95% CI 1.36–1.71, p<0.001). The risk was greater in elderly-onset UC patients (OR 1.61, 95% CI 1.39–1.87, p<0.001) compared to elderly-onset CD patients (OR 1.37, 95% CI 1.13–1.68, p=0.002). To address the potential misclassification of ischemic colitis as IBD, a subgroup analysis of ulcerative pancolitis patients was performed which also suggested an association between PAD and EO-IBD (OR 1.38, 95% CI 0.94–2.01, p=0.10). Conclusions: PAD was associated with an increased risk of EO-IBD suggesting that vascular factors may contribute to EO-IBD pathogenesis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".