DOP057 Perianal pediatric Crohn's disease is associated with a distinct phenotype and greater inflammatory burden
Bibliographic record
Abstract
Background: Data on the outcomes of children with perianal Crohn's disease (pCD) are limited, although its presence is often used for justifying early use of biologics. We aimed to assess whether pCD in children is associated with more severe outcomes as found in adults. Methods: Data were extracted from the ImageKids database, a prospective, multicenter, longitudinal cohort study. The study enrolled 246 children at disease onset or thereafter. All patients underwent comprehensive clinical, endoscopic, and radiologic evaluation at enrollment; 98 children had repeat evaluation at 18 months. Results: Of the 234 included patients [mean age 14.2±2.4 years; 131 (56%) males], 57 (24%) had perianal findings while only 21 (9%) had fistulizing perianal disease. Children with pCD had reduced weight and height z-scores compared with non-pCD patients (−0.9 vs. −0.35, p=0.03 and −0.68 vs. −0.23, respectively; p=0.04), higher weighted pediatric Crohn's disease activity index [32 (IQR 16–50) vs. 20 (8–37); p=0.004], lower serum albumin (3.6±0.7 vs. 4.5±0.8, p=0.016) and higher magnetic resonance enterography (MRE) global inflammatory score (p=0.04). Children with pCD had more rectal (57% vs. 38%, p=0.04), and jejunal involvement (31% vs. 11% p=0.003) and a higher prevalence of granulomas (64% vs. 23%, p=0.0001). MRE-based damage scores did not differ between groups. Patients with skin tags/fissures only, had similar clinical, endoscopic and radiologic characteristics as patients with no perianal findings. Conclusions: Pediatric pCD patients with fistulizing disease have distinct phenotypic features and a predisposition to a greater inflammatory burden.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".