P699 Impact of adalimumab's patient support program on clinical outcomes in inflammatory bowel diseases: results from the COMPANION study
Bibliographic record
Abstract
Background: Adalimumab (ADL) is an anti-TNF biologic therapy indicated for the treatment of inflammatory bowel diseases (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). Patients receiving ADL in Canada are eligible to enroll in the AbbVie Care patient support program (PSP) which provides them with personalized services including ongoing care coach calls (CCC). In a previous study, IBD patients enrolled in Abbvie Care receiving CCC demonstrated significantly greater persistence and adherence to ADL than patients that did not receive CCC (no-CCC). The objective of this study is to compare the likelihood of achieving clinical remission in a cohort of IBD patients treated with ADL enrolled in the ADL PSP between those who received CCC versus those who did not receive CCC. Methods: A longitudinal analysis using de-identified aggregate-level data collected through the AbbVie Care PSP was performed. Patients were indexed on the date of their first injection of ADL between January 2010 and October 2015. The ADL PSP database included patient measurements of the Harvey-Bradshaw Index (HBI), a measure of disease severity. To be eligible, patients had to have a baseline HBI measurement 90 days before to 30 days after their index date and have had a follow up HBI measurement 6 to 18 months later. HBI remission (HBI≤4) at the time of the follow up HBI assessment was compared in patients having received CCC and patients without CCC (no CCC). Robust Poisson regression was used to estimate the adjusted relative risk (RR) of HBI remission. Analyses were adjusted for patient age group, sex, region, prior biologic use, days lapsed between HBI assessments, and baseline disease severity category. Results: A total of 1469 IBD patients met eligibility criteria and 916 (62%) of these had received CCC. Of the 1469 patients, 1046 (71%) were in HBI remission at the second assessment, 682 (74%) in the CCC group and 364 (66%) in the group not receiving CCC. In the multivariable regression analysis, there was a 12% increased likelihood of achieving HBI remission in the CCC group relative to the group without CCC (RR=1.12, 95% confidence interval: 1.04, 1.20; p-value =0.002). Conclusions: IBD patients receiving tailored services through the ADL PSP in the form of care coach calls have an increased likelihood of achieving HBI remission within 6 to 18 months. These results may help refine interventions aiming at improving clinical outcomes in IBD patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".