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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

2017· article· en· 898 citations· W2587686129 on OpenAlex· 10.1038/nature21356

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.008
GPT teacher head0.268
Teacher spread
0.260 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Cancer Genomics and Diagnostics
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
SickKids FoundationHospital for Sick Children
Funders
National Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesNational Cancer Institute
Keywords
Extrachromosomal DNABiologyMetaphaseOncogeneGeneticsGenomeGeneCancerHuman geneticsChromosomeHuman genomeComputational biologyCell cycle
Has abstract in OpenAlex
no