Factors that predict remission of infant eczema
Bibliographic record
Abstract
Background The prognosis of infant atopic dermatitis (AD) is important for decision making of healthcare professionals, and stakeholders. The aim of this study was to investigate predictors for remission of infant AD until school age. Methods A systematic review was carried out of clinical and epidemiological studies investigating the effect of filaggrin gene (FLG) loss-of-function mutations, sex, exposure to pets, topical anti-inflammatory treatment, disease severity, and atopic sensitization during infancy on complete remission of infant-onset AD until 6–7 years of age. Systematic electronic searches until September 2013, data abstraction, and study quality assessment (Newcastle-Ottawa Scale) were performed. Results From 3,316 abstracts identified, 2 studies of good study quality were included with a total of 4230 patients. Parental allergies and sex did not significantly affect remission. For non-remission of AD, the included articles reported an association with any atopic sensitization at 2 years old (adjusted odds ratio [aOR] 2.76; 95% confidence interval (CI) 1.29–5.91), frequent scratching with early AD (aOR 5.86; 95% CI 3.04–11.29), objective severity score at 2 years old (aOR 1.10; 95% CI 1.07–1.14), and exposure to pets (cat OR 2.33; 95% CI 0.85–6.38). Conclusions It is largely unknown which factors predict remission of infant AD. This is a highly relevant research gap that hinders evidence based decision making regarding secondary prevention of AD. Based on current knowledge, severe cases of AD and cases with sensitization are risk groups which should be especially focused on in order to increase remission. Changes in life style should not be recommended based on current evidence. Early successful treatment maybe the best option for secondary prevention of AD. Key messages This is a highly relevant research gap that hinders evidence based decision making regarding secondary prevention of AD and more well performed longitudinal studies are needed As yet, there is no evidence that families need to adjust their life style for secondary prevention of AD. Early successful treatment maybe the beneficial for secondary prevention of AD
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.035 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".