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Record W2587822335 · doi:10.1016/j.cmet.2017.01.009

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx

2017· article· en· W2587822335 on OpenAlexaff
Harini Chakravarthy, Xueying Gu, Martin Enge, Xiao-Qing Dai, Yong Wang, Nicolas Damond, Carolina G Downie, Kathy Liu, Jing Wang, Yuan Xing, Simona Chera, Fabrizio Thorel, Stephen R. Quake, José Oberholzer, Patrick E. MacDonald, Pedro L. Herrera, Seung K. Kim

Bibliographic record

VenueCell Metabolism · 2017
Typearticle
Languageen
FieldMedicine
TopicPancreatic function and diabetes
Canadian institutionsUniversity of Alberta
FundersBoston Center For Blind ChildrenSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Institutes of HealthInstitute of Genetics and Genomics of GenevaNovo Nordisk FondenAgricultural Research Development AgencyNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteHoward Hughes Medical InstituteJuvenile Diabetes Research Foundation United States of AmericaEuropean CommissionCalifornia Institute of Regenerative Medicine
KeywordsBiologyDNMT1CellCell biologyIsletPAX4GlucagonEnteroendocrine cellCell typeInsulinEndocrinologyInternal medicineHomeoboxGeneGene expressionDNA methylationGeneticsMedicineEndocrine system

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.227
Teacher spread0.220 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations215
Published2017
Admission routes1
Has abstractno

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