SP024MURINE RECOMBINANT ACE2 ATTENUATES KIDNEY INJURY IN EXPERIMENTAL ALPORTS SYNDROME (AS)
Bibliographic record
Abstract
Introduction and Aims: ACE2 is a monocarboxypeptidase in the renin angiotensin systemthat catalyzes the breakdown of Angiotensin II (AngII) to Ang1-7. We have reported that ACE2 expression and activity in the kidney are reduced in experimental AS but the impact of this finding on kidney disease progression has not been studied. Accordingly, we evaluated the effects of treatment with murine recombinant ACE2 (mrACE2) inCol4A3-/- mice, a model of AS characterized by proteinuria and progressive renal injury. Methods: The mrACE2 was administered from 4 -7 weeks of agevia osmotic mini-pump (0.5mg/kg/day). Results: Treatment with mrACE2 led to an increase in both kidney renal ACE2 expression and the urinary ACE2 excretion rate in 7-week-old Col4A3-/- mice compared to untreated group. Kidney AngII levels declined and kidney Ang1-7 levels increased. These effects were associated with a significant decrease in proteinuria in the treated 7-week-old Col4A3-/- mice compared to the untreated group. The inflammatory cytokine IL-6and F4/80, a macrophage marker,werealso reduced by treatment withmrACE2. Transforming growth factor-β1 (TGF-β1),col1α1, and alpha smooth muscle actinlevels were increased in the kidneys of 7-week-old Col4A3-/- mice and all were reduced by mrACE2.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".