SP103IMPACT OF RENAL DENERVATION (RDN) ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD): PRAIRIE RDN STUDY
Bibliographic record
Abstract
Introduction and Aims: Accumulating evidence demonstrates that central aortic blood pressures (CBP) compared to the blood pressure (BP) measured at the brachial artery correlates better with adverse cardiovascular outcomes. We investigated the impact of RDN on central blood pressures and pulse wave velocities in patients with stage III and IV CKD with resistant hypertension. Methods: Twenty-six patients with resistant hypertension from our multidisciplinary CKD clinic underwent either unilateral or bilateral RDN from February 2013 to August 2014. CBP, 24-hour ambulatory blood pressures, average of 6 office BP readings on BP Tru, along with carotid-femoral pulse wave velocities were measured at 3,6,12 and 18 months. Seven patients withdrew, died or transitioned to dialysis leaving a final cohort of 19 patients for analysis. Results: Baseline (mean ± standard deviation) central systolic/diastolic blood pressures (mm Hg) were 131±22.57/ 77.09±16.36 and at 18 months were 120.16±14.67/ 70.58±14.35 respectively. In contrast the 24-hr ambulatory blood pressures (mm Hg) at baseline and 18 month were 142.8±16.27/65.63± 11.59 and 145.34± 13.99/66.53±13.36. Central pulse pressures (mm Hg) at baseline and 18-month post-RDN were 55.59±25.17 and 49.54±20.07 respectively. Similarly, the augmentation pressures at baseline and 18 month were: 14.09±11.35 and 11.32±11.52 mm Hg respectively. Augmentation index (%) was 22.86±11.98 at baseline and 18.45±12.63 at 18 months. Pulse wave velocity was 15.95 (14.15) at baseline and 15.03 (4.93) at 18 months. MDRD GFR in mls/min/1.73m2 at baseline and 18 months were: 39.3±14.34 and 36.67±17.83 respectively.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".