MNGO-09. PROGNOSTIC SIGNIFICANCE OF PRE-OPERATIVE ANEMIA AND LEUKOCYTOSIS ON RECURRENCE-FREE SURVIVAL IN MENINGIOMA
Bibliographic record
Abstract
Definite pretreatment predictors for tumor recurrence in meningioma are not well defined. Several studies in solid malignant tumors from various sites including glioblastoma have indicated the association of pre-treatment anemia and/or changes in number of leukocytes in peripheral blood with patient outcomes. We hypothesized those changes in complete blood count (CBC) before tumor resection can be used as one of the prognostic factors for tumor recurrence in meningioma. We gathered the clinical and pathological data from 226 histologically confirmed meningioma patients as well as results of CBC collected within 1 week before neurosurgical resection conducted at the Toronto Western Hospital between 2001 and 2015. Results were compared with recurrence-free survival (RFS) using univariable and multivariable analyses. Using standard cut-offs in our laboratory, anemia, leukocytosis and neutrophilia were identified in 56 (25%), 59 (26%) and 70 (31%) patients, respectively. These were distributed in patients among all 3 grades. The majority of patients had normocytic anemia (45/56). On univariate analysis, the presence of anemia (P=0.0003), leukocytosis (P=0.0123), and neutrophilia (P=0.0008) correlated with worse RFS. We found combined leukocytosis and anemia in 27/226(12%) patients who had a particularly poor outcome. On multivariable analysis after adjustment for malignancy grade and extent of resection, leukocytosis plus anemia remained independently prognostic for RFS (P<0.0001, HR=5.35). Lymphopenia and monocytosis were observed in 88(39%) and 32 (14%) of patients, respectively and both of them showed a trend toward poorer RFS. The presence of anemia, leukocytosis in the pre-operative CBC may suggest tumor recurrence in patients with meningioma and should be examined in additional cohorts. Further studies to explain the effect of pre-treatment anemia and changes in number of leukocytes, neutrophils and lymphocytes in peripheral blood on tumor progression and risk stratification of these patients are needed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".