Patterns of radiation therapy technology use in the treatment of bone metastases.
Bibliographic record
Abstract
211 Background: In recent years, there has been a transition from two-dimensional radiation therapy (2DRT) planning towards more advanced techniques such as three-dimensional conformal radiation therapy (3D-CRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT). Our study aim was to analyze these trends in the treatment of bone metastases. Methods: All patients aged 18 and older who had received palliative intent RT for bone metastases between 2009-2014 and referred to any 1 of 6 regional cancer centers in British Columbia, Canada were reviewed. Summary statistics were used to describe radiation technique patterns. Logistic regression modeling was used to assess the influence of demographic, clinical, and health services variables on receipt of types of RT. Results: We identified 8,059 patients and 15,832 courses of RT; overall, 97.9% of courses were achieved by 2DRT and 2.1% by 3D-CRT, VMAT, or SBRT. Despite the low overall use of advanced techniques, its use was significantly higher in all subsequent years compared to 2009 (p < 0.05 for all years). The median age for patients treated with 2DRT was 67.0 (19-99) versus 66.0 years (19-93) for advanced techniques. There did not appear to be a statistically significant difference in age at the time of treatment start (OR 0.99; 95% CI 0.981-1.00, p < 0.05). Compared to lung cancers, thyroid (OR 9.9; 95% CI 5.197-18.724, p < 0.001) and kidney cancers (OR 3.9; 95% CI 2.508-5.911, p < 0.001) were significantly more likely to be treated with advanced techniques, while breast (OR 0.90; 95% CI 0.621-1.306, p = 0.58) and prostate cancers (OR 0.93; 95% CI 0.613-1.410, p = 0.73) were not any more likely. Compared to the Vancouver center, all other treatment centers in the province were utilizing advanced techniques less frequently. Patients were also more likely to complete RT with 2DRT than with advanced techniques (98.3% versus 95.8%, p < 0.05). Conclusions: The vast majority of treatment of bone metastases is still done by 2DRT in British Columbia. Despite these overall statistics though, a trend towards increasing use of more advanced techniques was observed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".