Retrospective review of FOLFIRI with or without bevacizumab (bev) for patients (pts) with metastatic colorectal cancer (mCRC): Reviewing a single-center standard clinical practice.
Bibliographic record
Abstract
434 Background: Use of bev with FOLFIRI proved, in clinical trials, to be well tolerated and clinically effective in mCRC pts. In this single-center retrospective review we assess outcomes of mCRC pts on standard first-line treatment with FOLFIRI alone and FOLFIRI bev in routine care. Methods: Patients treated with FOLFIRI at TOHCC from Jan 1, 2004 to Aug 10, 2010 on a first-line mCRC were followed until August 10, 2012. According to bev availability three groups of pts can be identified: treated with FOLFIRI bev and treated with FOLFIRI alone before and after bev availability (Sept 5, 2005). Results: Of 526 pts, 470 (89%) were eligible; 176 (37%) treated with FOLFIRI with bev and 294 (63%) with FOLFIRI alone—127 (43%) before and 167 (57%) after bev availability. At the start of FOLFIRI therapy there was no significant difference among the 3 groups: median age 62 (range 36-83), 61 (32-81), 64 (28-85) years, male 54%, 72%, 64%, respectively. Pts treated with FOLFIRI bev received a median 19 cycles (range 2-78) of FOLFIRI and a median of 15 cycles (range 2-63) of bev; 89 (51%) discontinued bev before FOLFIRI. Pts treated with FOLFIRI alone received a median 12 cycles (range 3-35) before bev availability and 13 cycles (2-48) after. Toxicity was responsible for at least 1 dose adjustment in 146 (83%) pts on FOLFIRI bev and 215 (73%) pts on FOLFIRI alone. Bev was held in 95 (54%) pts; once 35%, twice 25%. The median time off bev was 37 days. Median PFS was 17 months (95%CI 13-20) for patients treated with FOLFIRI bev. When we consider patients treated with FOLFIRI before bev availability median PFS was 13 mo (95%CI 10-17) and 14 mo (95%CI 10-16) when we consider pts post bev availability. Over a period of 3 years the survival rates in three groups of pts (FOLFIRI bev, FOLFIRI alone before bev availability, FOLFIRI alone post bev availability) were 1 year 90%, 77%, and 78%; 2 years 67%, 49%, and 56%; 3 years 54% , 31%, and 44%. Conclusions: Pts treated with FOLFIRI bev received more cycles of chemotherapy however with more dose adjustments. There is a relevant benefit in terms of PFS and a more substantial advantage in terms of 1, 2 and 3 years survival rates with the addition of bev to FOLFIRI.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.017 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.006 | 0.010 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".