Phase I/II study of tumor-infiltrating lymphocyte (TIL) infusion and low-dose interleukin-2 (IL-2) in patients with advanced malignant pleural mesothelioma (MPM).
Bibliographic record
Abstract
TPS7586 Background: MPM is a disease with poor outcomes, and only modest benefits from existing systemic therapies. Preclinical studies have shown that MPM often contains populations of TILs, and that these can be expanded ex vivo. Therapy using autologous TIL infusions and IL-2 following lymphodepleting chemotherapy has been successfully used in advanced melanoma. The therapeutic potential for TILs in MPM has not yet been explored. Methods: This is a single arm, phase I/II study to evaluate the feasibility, safety, and efficacy of TIL therapy for advanced MPM at the Princess Margaret Cancer Centre. Eligibility criteria include: advanced MPM, suitable surgical candidate for TIL harvesting from tumor, ECOG performance status 0-1, adequate organ function, and successful expansion of TILs. TILs are harvested from fresh tumor tissue, evaluated for suitability, and expanded ex-vivo. Patients are treated with a lymphodepleting chemotherapy regimen containing cyclophosphamide (60mg/m2 x 2 days) and fludarabine (25mg/m2 x 5 days), followed by infusion of expanded TILs. This is followed by low-dose IL-2 therapy (125000 IU/kg/day subcutaneously) for 2 weeks. The treatment protocol is adapted from that used in melanoma TIL studies, and no dose exploration is planned. The primary objective is determining the feasibility and safety of the regimen. Efficacy as measured by objective response rate (modified RECIST) is a secondary objective. The planned sample size is 10 patients. An informal interim analysis will be performed after 6 patients have been treated to review treatment toxicities and feasibility, given the lack of previous experience with this treatment in MPM. Correlative studies include analysis of peripheral blood mononuclear cells and assessment of persistence of infused TILs. Patients are currently being screened for TIL expansion at the Princess Margaret Cancer Centre.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".