Abstract 530: Diurnal and Day-to-Day Variability of Endothelial Progenitor Cells
Bibliographic record
Abstract
Background Circulating endothelial progenitor cells (EPCs) may contribute to vascular repair. Whether a diurnal and/or day-to-day variability of circulating EPCs is physiologically present in healthy adults has not been investigated. Methods Eighteen healthy adults underwent EPCs count on three different time points: two in the same day between 7:00 and 8:30 and between 12:30 and 14:00; and one in another day between 7:00 and 8:30. EPCs (CD34+CD45lo; CD34+CD45loCD133+; and CD34+CD45loCD31+) were quantified using multi-parameter flow cytometry and an ISHAGE based gating strategy. Variability of EPCs was assessed by coefficient of variation (CV) between time points in the same day and in different days. Results Baseline participant characteristics are reported in table 1. EPCs measurements and CVs are reported in table 2. Conclusions In healthy middle-aged adults, circulating EPCs appear to have a marked diurnal variability but a low day-to-day variability. Further study is needed to understand the mechanisms of EPCs variability and its biological significance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".