Oligofructose decreases serum lipopolysaccharide and plasminogen activator inhibitor‐1 in adults with overweight/obesity
Why this work is in the frame
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Bibliographic record
Abstract
Objective To determine the effect of prebiotic supplementation on metabolic endotoxemia and systemic inflammation in adults with overweight and obesity. Methods Samples from a previously conducted randomized, double‐blind, placebo‐controlled trial were used for analysis. Participants were randomized to 21 g of oligofructose ( n = 20; BMI 30.4 kg/m 2 ) or a maltodextrin placebo ( n = 17; BMI 29.5 kg/m 2 ) for 12 weeks. A total of 37 participants had samples available for the current analysis. Resistin, adiponectin, plasminogen activator inhibitor‐1 (PAI‐1), interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and macrophage chemoattractant protein‐1 (MCP‐1) were quantified using MILLIPLEX® assays. Lipopolysaccharide (LPS) was measured using PyroGene™ Recombinant Factor C Assay. Results Plasma LPS concentrations were reduced by 40% in the oligofructose group over 12 weeks compared to a 48% increase in the placebo group ( P = 0.04). PAI‐1, a risk factor for thrombosis, was reduced to a greater extent in the oligofructose group (−17.3 ± 2.6 ng/ml) compared to the placebo group (−9.7 ± 1.8 ng/ml; P = 0.03). Oligofructose did not affect IL‐6, TNF‐α, MCP‐1, adiponectin, or resistin. Conclusions Oligofructose reduces metabolic endotoxemia and PAI‐1. Incorporating prebiotics into the diet through supplements or functional foods may help mitigate some markers of obesity‐associated inflammation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it