Indirect comparisons of efficacy and weekly factor consumption during continuous prophylaxis with recombinant factor <scp>VIII</scp> Fc fusion protein and conventional recombinant factor <scp>VIII</scp> products
Bibliographic record
Abstract
Introduction Recombinant factor VIII ( rFVIII ) products with extended half‐lives have the potential to improve adherence and outcomes in haemophilia beyond the results obtained with conventional rFVIII products. Aim In the absence of head‐to‐head comparisons, annualized bleed rates ( ABR s) and weekly factor consumption with rFVIII Fc fusion protein ( rFVIIIF c) and conventional rFVIII products were indirectly compared using studies of continuous prophylaxis. Methods A systematic literature review was conducted to identify studies of rFVIII products for comparison with rFVIIIF c in the continuous prophylactic treatment of previously treated adolescents and adults with moderate and severe haemophilia A. Mean ABR s were compared between rFVIIIF c and individual rFVIII studies and between rFVIIIF c and a pooled measure for rFVIII estimated by meta‐analysis. Comparisons of factor consumption were based on mean or median weekly factor consumption. Results Results from seven studies of conventional rFVIII products (injections 2–4 times week −1 ) were compared with rFVIIIF c (injections 1.4–2.4 times week −1 ). The pooled mean ABR for rFVIII products was significantly higher compared with rFVIIIF c (difference = 2.0; P = 0.007). Compared with most rFVIII studies, the reported weekly factor consumption was lower with rFVIIIF c [mean differences = 15.5–21.8 IU kg −1 week −1 (17–26%); median differences = 12.7–29.8 IU kg −1 week −1 (16–37%)]. In one comparison, mean weekly factor consumption with rFVIII was significantly lower but mean ABR was significantly higher than rFVIIIF c. Conclusion Prophylaxis with rFVIIIF c may be associated with improved bleeding rates and lower weekly factor consumption than more frequently injected rFVIII products. Relative to rFVIII products with similar bleeding rates, results indicate that rFVIIIF c is associated with reduced weekly factor consumption while requiring fewer prescribed injections.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".