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Record W2594377495 · doi:10.7439/ijap.v3i6.3803

Drug Dosing in Obese Patients: A Dilemma

2014· article· en· W2594377495 on OpenAlexaff
Anshika Kaul, Mir Adil

Bibliographic record

VenueScholar Science Journals - International Journal of Biomedical Research · 2014
Typearticle
Languageen
FieldMedicine
TopicPharmacology and Obesity Treatment
Canadian institutionsASTER
Fundersnot available
KeywordsDosingMedicineObesityPharmacokineticsTherapeutic indexDrugClinical trialIntensive care medicineInternal medicinePharmacology

Abstract

fetched live from OpenAlex

Prevalence of obesity has increased over the past few years and is still growing. Usually obesity is accompanied by co-morbid conditions which may be caused because of it too. Due to this it is not unusual for a physician to have a lot of obese patients. Now, the dosing of the drug is a major issue. The dose given for normal patients may not be accurate for obese patients and it is highly likely to worsen the condition of the patient on account of the fact that pharmacokinetic parameters of an obese individual differs from a normal person. During clinical trials, the dose is calculated for normal weight patients, but the scenario changes in obese. Due to the lack of sufficient evidence, the dose modification poses to be a threat to patients especially the ones who are on drugs with a narrow therapeutic index. Various scales have been formulated to help but more research needs to be done to get precise doses.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.023
metaresearch head score (Gemma)0.013
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.401
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0230.013
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0030.002
Science and technology studies0.0000.001
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0000.003
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.065
GPT teacher head0.484
Teacher spread0.419 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2014
Admission routes1
Has abstractyes

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