Characterization of anti-inflammatory effect and possible mechanism of action of <i>Tibouchina granulosa</i>
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
OBJECTIVES: Tibouchina granulosa, popularly known as 'quaresmeira', belong to a genus widely used in the traditional medicine as infusions from their leaves. Other species of Tibouchina are used as antibacterial, antioxidant or antileishmanial. In this work, our objectives were to investigate the biological effects of T. granulosa in models of acute inflammation. METHODS: Chemical analysis showed the presence of proanthocyanidins and flavonoids. Infusions from leaves of T. granulosa (1, 3, 10, 30 or 100 mg/kg) were orally administered to mice, and the anti-inflammatory effects were evaluated by the formalin-induced licking response, inhibition of carrageenan-induced cell migration into subcutaneous air pouch (SAP) and inhibition of inflammatory mediator production in inflammatory exudate collected from SAP. KEY FINDINGS: Our data indicate that tested doses of T. granulosa infusion reduced cell migration, protein extravasated to SAP and cytokine production (i.e. TNF-α and IL-10). All doses also inhibited the first and second phase of formalin-induced licking response. CONCLUSIONS: Taken together, our results indicate that leaves of T. granulosa present anti-inflammatory effect and can be useful in the preparation of new phytomedicines.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it